Vilček S, Jacková A, Kolesárová M, Vlasáková M
Acta Virol. 2017;61(2):212-216. doi: 10.4149/av_2017_02_12.
Bovine coronavirus (BCoV) is considered an important pathogen in cattle worldwide. It is a causative agent of enteric and respiratory diseases of cattle. The S1 subunit of the viral S glycoprotein is responsible for virus binding to host-cell receptors, induction of neutralizing antibody and hemagglutinin activity. The entire S1 genomic region (2304 bp) of two enteric bovine coronavirus isolates from Austria, one respiratory and one enteric isolate from Slovakia were analyzed at the genetic level. The comparative analysis of those four isolates revealed 97.1-98.6% similarity at the nucleotide and 95.6-98.6% at the amino acid level. No differences between enteric and respiratory isolates were observed at the genetic level. The isolates were clustered in the phylogenetic tree with European isolates independently of their enteric or respiratory origin.
牛冠状病毒（BCoV）被认为是全球牛群中的一种重要病原体。它是牛肠道和呼吸道疾病的病原体。病毒S糖蛋白的S1亚基负责病毒与宿主细胞受体的结合、中和抗体的诱导以及血凝素活性。对来自奥地利的两株肠道牛冠状病毒分离株、来自斯洛伐克的一株呼吸道分离株和一株肠道分离株的整个S1基因组区域（2304 bp）进行了基因水平分析。对这四株分离株的比较分析显示，核苷酸水平上的相似度为97.1-98.6%，氨基酸水平上的相似度为95.6-98.6%。在基因水平上未观察到肠道分离株和呼吸道分离株之间的差异。这些分离株在系统发育树中与欧洲分离株聚类，而与它们的肠道或呼吸道来源无关。
