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本文引用的文献

1
Molecular analysis of S gene of spike glycoprotein of winter dysentery bovine coronavirus circulated in Korea during 2002-2003.2002 - 2003年在韩国流行的冬季痢疾牛冠状病毒刺突糖蛋白S基因的分子分析
Virus Res. 2005 Mar;108(1-2):207-12. doi: 10.1016/j.virusres.2004.07.003.
2
Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event.人冠状病毒OC43的完整基因组序列：分子钟分析表明最近发生了一次人畜共患冠状病毒传播事件。
J Virol. 2005 Feb;79(3):1595-604. doi: 10.1128/JVI.79.3.1595-1604.2005.
3
Reasoning of spike glycoproteins being more vulnerable to mutations among 158 coronavirus proteins from different species.在来自不同物种的158种冠状病毒蛋白中，刺突糖蛋白更容易发生突变的原因。
J Mol Model. 2005 Feb;11(1):8-16. doi: 10.1007/s00894-004-0210-0. Epub 2004 Dec 9.
4
Human respiratory coronavirus OC43: genetic stability and neuroinvasion.人类呼吸道冠状病毒OC43：基因稳定性与神经侵袭
J Virol. 2004 Aug;78(16):8824-34. doi: 10.1128/JVI.78.16.8824-8834.2004.
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A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae.一项用于修订冠状病毒科当前分类法的比较序列分析。
Arch Virol. 2003 Nov;148(11):2207-35. doi: 10.1007/s00705-003-0162-1.
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Identification of a receptor-binding domain of the spike glycoprotein of human coronavirus HCoV-229E.人冠状病毒HCoV-229E刺突糖蛋白受体结合结构域的鉴定
J Virol. 2003 Feb;77(4):2530-8. doi: 10.1128/jvi.77.4.2530-2538.2003.
7
Conformational changes in the spike glycoprotein of murine coronavirus are induced at 37 degrees C either by soluble murine CEACAM1 receptors or by pH 8.鼠冠状病毒刺突糖蛋白的构象变化在37摄氏度时可由可溶性鼠CEACAM1受体或pH值为8时诱导产生。
J Virol. 2003 Jan;77(2):830-40. doi: 10.1128/jvi.77.2.830-840.2003.
8
Molecular analysis of the S1 subunit of the spike glycoprotein of respiratory and enteric bovine coronavirus isolates.呼吸道和肠道牛冠状病毒分离株刺突糖蛋白S1亚基的分子分析
Virus Res. 2002 Mar 20;84(1-2):101-9. doi: 10.1016/s0168-1702(02)00004-7.
9
Comparison of genomic and predicted amino acid sequences of respiratory and enteric bovine coronaviruses isolated from the same animal with fatal shipping pneumonia.从同一患有致命运输性肺炎的动物中分离出的呼吸道和肠道牛冠状病毒的基因组及预测氨基酸序列的比较
J Gen Virol. 2001 Dec;82(Pt 12):2927-2933. doi: 10.1099/0022-1317-82-12-2927.
10
Genomic and antigenic variations of the HE glycoprotein of bovine coronaviruses associated with neonatal calf diarrhea and winter dysentery.与新生犊牛腹泻和冬季痢疾相关的牛冠状病毒血凝素酯酶糖蛋白的基因组和抗原变异
Arch Virol. 2001;146(6):1219-30. doi: 10.1007/s007050170117.

巴西牛冠状病毒（BCoV）毒株的分子分析显示，在刺突糖蛋白S1亚基的高变区内存在一个缺失，该缺失在人冠状病毒OC43中也有发现。

Molecular analysis of Brazilian strains of bovine coronavirus (BCoV) reveals a deletion within the hypervariable region of the S1 subunit of the spike glycoprotein also found in human coronavirus OC43.

作者信息

Brandão P E, Gregori F, Richtzenhain L J, Rosales C A R, Villarreal L Y B, Jerez J A

机构信息

Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil.

出版信息

Arch Virol. 2006 Sep;151(9):1735-48. doi: 10.1007/s00705-006-0752-9. Epub 2006 Apr 3.

DOI:10.1007/s00705-006-0752-9
PMID:16583154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7086848/
Abstract

Bovine coronavirus (BCoV) causes enteric and respiratory dis- orders in calves and dysentery in cows. In this study, 51 stool samples of calves from 10 Brazilian dairy farms were analysed by an RT-PCR that amplifies a 488-bp fragment of the hypervariable region of the spike glycoprotein gene. Maximum parsimony genealogy with a heuristic algorithm using sequences from 15 field strains studied here and 10 sequences from GenBank and bredavirus as an outgroup virus showed the existence of two major clusters (1 and 2) in this viral species, the Brazilian strains segregating in both of them. The mean nucleotide identity between the 15 Brazilian strains was 98.34%, with a mean amino acid similarity of 98%. Strains from cluster 2 showed a deletion of 6 amino acids inside domain II of the spike protein that was also found in human coronavirus strain OC43, supporting the recent proposal of a zoonotic spill- over of BCoV. These results contribute to the molecular characterization of BCoV, to the prediction of the efficiency of immunogens, and to the definition of molecular markers useful for epidemiologic surveys on coronavirus-caused diseases.

摘要

牛冠状病毒（BCoV）可导致犊牛出现肠道和呼吸道疾病以及奶牛出现痢疾。在本研究中，采用逆转录聚合酶链反应（RT-PCR）对来自10个巴西奶牛场的51份犊牛粪便样本进行了分析，该方法可扩增刺突糖蛋白基因高变区的一个488碱基对片段。利用本研究中15个田间毒株的序列以及来自GenBank的10个序列，并以繁殖病毒作为外群病毒，通过启发式算法构建的最大简约系统发育树显示，该病毒种存在两个主要簇（1和2），巴西毒株分布于这两个簇中。15个巴西毒株之间的平均核苷酸同一性为98.34%，平均氨基酸相似性为98%。簇2中的毒株在刺突蛋白结构域II内有6个氨基酸缺失，这在人冠状病毒OC43毒株中也有发现，支持了BCoV人畜共患溢出的最新观点。这些结果有助于BCoV的分子特征分析、免疫原效率预测以及确定对冠状病毒引起疾病进行流行病学调查有用的分子标记。