Zakharova I A, Avdeev R V, Pristavka V A, Surnin S N, Makhmutov V Yu, Savrasova I I
N.N. Burdenko Voronezh State Medical University, 10 Studencheskaya St., Voronezh, Russian Federation, 394036.
Saint Joasaph Belgorod Regional Clinical Hospital, 7/8 Nekrasova St., Belgorod, Russian Federation, 308007.
Vestn Oftalmol. 2017;133(2):22-28. doi: 10.17116/oftalma2017133222-28.
to investigate neuromidin effectiveness in the treatment of patients with primary glaucoma and compensated intraocular pressure (IOP).
A total of 40 patients (80 eyes) were examined. Of them, 10 eyes with early glaucoma, 36 eyes with moderate-stage glaucoma, 33 eyes with advanced glaucoma, and 1 eye with end-stage glaucoma. In 19 eyes, IOP was controlled through beta-blockers, in 11 eyes - through carbonic anhydrase inhibitors, in 10 eyes - through prostaglandin analogues, and in 39 eyes - through combination drugs. Twenty-six eyes had received glaucoma surgery some time earlier. Ipidacrine was prescribed in tablets at 20 mg 2 times daily for 25 days. Treatment effectiveness was judged by visual functions, hydrodynamics, and morphometric parameters of the optic disc.
In moderate-stage eyes, visual acuity improved in 66.6% of cases and remained unchanged in 33.3%. In advanced-stage eyes, visual acuity improved in 51.5% of cases and remained unchanged in 48.5%. Visual field broadened in all cases. Moreover, under the neuromidin therapy, the number of scotomas in early-stage eyes decreased, while the number of areas with normal sensitivity of the retina increased by 14.9%. In advanced-stage glaucoma, the effect was less pronounced: the number of type 1 and type 2 scotomas decreased by 3.0±0.6% and 2.9±0.8%, respectively; the number of absolute scotomas did not change; the number of areas with normal sensitivity of the retina increased by 7.4±2.0%. Also, P0 was found to be reduced and intraocular fluid outflow - activated. In early and moderate glaucoma, there was a significant reduction in the cup area as well as an increase in the neuroretinal rim area and retinal nerve fiber layer thickness. In advanced-stage cases, it was only the retinal nerve fiber layer thickness that changed.
Neuromidin has a positive impact on visual function, hydrodynamics, and morphometric parameters of the optic disc.
研究神经调节素治疗原发性青光眼及眼压得到控制的患者的疗效。
共检查了40例患者（80只眼）。其中，10只眼为早期青光眼，36只眼为中期青光眼，33只眼为晚期青光眼，1只眼为终末期青光眼。19只眼通过β受体阻滞剂控制眼压，11只眼通过碳酸酐酶抑制剂控制眼压，10只眼通过前列腺素类似物控制眼压，39只眼通过联合用药控制眼压。26只眼曾在早些时候接受过青光眼手术。给予伊匹达克林片剂，每日2次，每次20mg，共服用25天。通过视功能、流体动力学及视盘的形态学参数来判断治疗效果。
在中期青光眼患者中，66.6%的病例视力提高，33.3%的病例视力保持不变。在晚期青光眼患者中，51.5%的病例视力提高，48.5%的病例视力保持不变。所有病例视野均变宽。此外，在神经调节素治疗下，早期青光眼患者的暗点数量减少，而视网膜正常敏感度区域的数量增加了14.9%。在晚期青光眼患者中，效果不太明显：1型和2型暗点数量分别减少了3.0±0.6%和2.9±0.8%；绝对暗点数量未改变；视网膜正常敏感度区域的数量增加了7.4±2.0%。此外，发现P0降低，房水流出增加。在早期和中期青光眼患者中，杯盘面积显著减小，神经视网膜边缘面积及视网膜神经纤维层厚度增加。在晚期病例中，仅视网膜神经纤维层厚度发生了变化。
神经调节素对视功能、流体动力学及视盘的形态学参数有积极影响。
