二氧化硫：生命的敌人还是朋友？
Sulfur dioxide: foe or friend for life?
作者信息
Wang Xin-Bao, Cui Hong, Liu Xiaohong, Du Jun-Bao
机构信息
Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, P.R. China.
Department of Pediatrics, Peking University First Hospital, Beijing, P.R. China.
出版信息
Histol Histopathol. 2017 Dec;32(12):1231-1238. doi: 10.14670/HH-11-904. Epub 2017 May 19.
Sulfur dioxide (SO₂) is a toxic gas and air pollutant. The toxic effects of SO₂ have been extensively studied. Oxidative damage due to SO₂ can occur in multiple organs. Inhaled SO₂ can also cause chromosomal aberrations, DNA damage and gene mutations in mammals. However, SO₂ can also be generated from the sulfur-containing amino acid, L-cysteine. Recent studies have shown that SO₂ has a vasorelaxant effect, and ameliorates pulmonary hypertension and vascular remodeling. SO₂ can also reduce lung injury and myocardial injury in rats. In addition, SO₂ reduces myocardial ischemia-reperfusion injury and atherosclerotic lesions. Therefore, SO₂ exerts both detrimental and protective effects in mammals. Is SO₂ a foe or friend for life?.
二氧化硫（SO₂）是一种有毒气体和空气污染物。二氧化硫的毒性作用已得到广泛研究。二氧化硫引起的氧化损伤可发生在多个器官。吸入的二氧化硫还可导致哺乳动物染色体畸变、DNA损伤和基因突变。然而，含硫氨基酸L-半胱氨酸也可产生二氧化硫。最近的研究表明，二氧化硫具有血管舒张作用，并可改善肺动脉高压和血管重塑。二氧化硫还可减轻大鼠的肺损伤和心肌损伤。此外，二氧化硫可减轻心肌缺血-再灌注损伤和动脉粥样硬化病变。因此，二氧化硫在哺乳动物中既产生有害作用，也发挥保护作用。二氧化硫对生命是敌还是友？
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