Valdiglesias Vanessa, Sánchez-Flores María, Maseda Ana, Lorenzo-López Laura, Marcos-Pérez Diego, López-Cortón Ana, Strasser Barbara, Fuchs Dietmar, Laffon Blanca, Millán-Calenti José C, Pásaro Eduardo
a Universidade da Coruña, DICOMOSA Group , Department of Psychology, Area of Psychobiology , A Coruña , Spain.
b Universidade da Coruña , Department of Cell and Molecular Biology , A Coruña , Spain.
J Toxicol Environ Health A. 2017;80(13-15):605-620. doi: 10.1080/15287394.2017.1286898. Epub 2017 May 19.
Aging is associated with a decline in the normal functioning of the immune system. Several studies described the relationship between immunological alterations, including immunosenescence and inflammation, and aging or age-related outcomes, such as sarcopenia, depression, and neurodegenerative disorders. Physical activity is known to improve muscle function and to exert a number of benefits on older adult health, including reduced risk for heart and metabolic system chronic diseases. However, the positive influence of physical activity on the immune system has not been elucidated. In order to shed light on the role of physical activity in immune responses of older individuals, a number of immunological parameters comprising % lymphocyte subsets (CD3, CD4, CD8, CD19, and CD1656) and serum levels of neopterin and tryptophan metabolism products were evaluated in peripheral blood samples of older adults performing normal (N = 170) or reduced (N = 89) physical activity. In addition, the potential influence of other clinical and epidemiological factors was also considered. Results showed that subjects with reduced physical activity displayed significantly higher levels of CD4/CD8 ratio, kynurenine/tryptophan ratio, and serum neopterin, along with lower %CD19 cells and tryptophan concentrations. Further, some immunological biomarkers were associated with cognitive impairment and functional status. These data contribute to reinforce the postulation that physical activity supports healthy aging, particularly by helping to protect the immunological system from aging-related changes.
衰老与免疫系统正常功能的衰退有关。多项研究描述了免疫改变（包括免疫衰老和炎症）与衰老或与年龄相关的结果（如肌肉减少症、抑郁症和神经退行性疾病）之间的关系。众所周知，体育活动可改善肌肉功能，并对老年人的健康产生诸多益处，包括降低心脏和代谢系统慢性疾病的风险。然而，体育活动对免疫系统的积极影响尚未得到阐明。为了阐明体育活动在老年人免疫反应中的作用，我们在进行正常（N = 170）或减少（N = 89）体育活动的老年人外周血样本中评估了多项免疫参数，包括淋巴细胞亚群百分比（CD3、CD4、CD8、CD19和CD1656）以及新蝶呤和色氨酸代谢产物的血清水平。此外，还考虑了其他临床和流行病学因素的潜在影响。结果显示，体育活动减少的受试者CD4/CD8比值、犬尿氨酸/色氨酸比值和血清新蝶呤水平显著更高，同时CD19细胞百分比和色氨酸浓度更低。此外，一些免疫生物标志物与认知障碍和功能状态相关。这些数据有助于强化这样一种假设，即体育活动有助于健康衰老，特别是通过帮助保护免疫系统免受与衰老相关的变化影响。
