通过硫脲催化的串联反应实现含氟四氢喹啉的不对称合成。
Asymmetric synthesis of CF-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction.
作者信息
Zhu Yuanyuan, Li Boyu, Wang Cui, Dong Zhenghao, Zhong Xiaoling, Wang Kairong, Yan Wenjin, Wang Rui
机构信息
The Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.
出版信息
Org Biomol Chem. 2017 May 31;15(21):4544-4547. doi: 10.1039/c7ob01013c.
PMID:28524917
Abstract
An organocatalytic asymmetric method for the synthesis of 2-CF tetrahydroquinoline has been achieved. The cascade reaction of 2-aminochalcones with β-CF nitroalkenes afforded the products bearing three contiguous stereogenic centers in good yields with excellent diastereoselectivities and enantioselectivities.
摘要
已实现一种用于合成2-三氟甲基四氢喹啉的有机催化不对称方法。2-氨基查耳酮与β-三氟甲基硝基烯烃的串联反应以良好的产率、优异的非对映选择性和对映选择性得到了含有三个相邻手性中心的产物。
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