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[HIV感染:实现零传播风险]

[HIV infection : Reaching a zero risk of transmission].

作者信息

Henrard S, Wyndham-Thomas C, Van Vooren J P, Goffard J C

机构信息

Centre de Référence SIDA, Unité de Traitements des Immunodéficiences, Hôpital Erasme, Route de Lennik 808, Bruxelles, Belgium.

出版信息

Rev Med Brux. 2016;37(4):315-321.

Abstract

Despite a global reduction in the prevalence of HIV-infection, the HIV-epidemic is far from over. The prevention of HIV-transmission in all its forms (sexual, mother-to-child etc) must therefore remain a pillar in the fight against AIDS, and both potent and accessible prevention strategies are required. In addition to the classical and wellknown methods such as the condom, ant iretroviral therapy represents a potent prevention tool and the residual risk of transmission of correctly treated HIV-positive persons is virtually nihil. Antiretroviral therapy may and should be used in the prevention of HIV-transmission as Treatment as Prevention (TasP), Pre-Exposure Prophylaxis (PrEP), and Post- Exposure Prophylaxis (PEP). However, because of their exorbitant costs, the accessibility of these prevention strategies is limited, particularly for the most vulnerable populations.

摘要

尽管全球范围内艾滋病毒感染率有所下降,但艾滋病毒流行远未结束。因此,预防各种形式的艾滋病毒传播(性传播、母婴传播等)必须仍然是抗击艾滋病斗争的一个支柱,并且需要有效且可及的预防策略。除了诸如避孕套等经典且广为人知的方法外,抗逆转录病毒疗法是一种有效的预防工具,接受正确治疗的艾滋病毒阳性者的残余传播风险几乎为零。抗逆转录病毒疗法可以而且应该作为预防艾滋病治疗(TasP)、暴露前预防(PrEP)和暴露后预防(PEP)用于预防艾滋病毒传播。然而,由于成本过高,这些预防策略的可及性有限,尤其是对最脆弱人群而言。

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