Cho Kwan Hyuk, Kim Chi Kyung, Oh Kyungmi, Oh Seung-Won, Park Kyu Hyung, Park Sang Jun
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea 2HanGil Eye Hospital, Incheon, Republic of Korea.
Department of Neurology, Korea University Guro Hospital and Korea University College of Medicine, Seoul, Republic of Korea.
Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO82-BIO87. doi: 10.1167/iovs.17-21413.
We investigated cerebral small vessel disease (SVD) in patients with incidental retinal vein occlusion (RVO).
This retrospective, case-control, observational trial included 125 patients with RVO who underwent brain magnetic resonance imaging (MRI) and 1105 age-matched controls who underwent comprehensive medical interviews and MRI. Underlying cardiovascular diseases and MRI findings were investigated in the patients with RVO according to age (<60 or ≥60 years) and RVO occlusion level (central or branch). The characteristics of underlying cardiovascular disease and MRI findings were compared between the younger patients with RVO and age-matched controls. The cerebrovascular burden also was assessed in the younger patients with RVO.
The mean age of the patients with RVO was 63.9 ± 12.1 years and the predominant underlying disease was hypertension (72/125, 58%). The older RVO group had a longer history of hypertension and less smoking history. The prevalence of cerebral SVD in the RVO group was 54% (68/125), and was significantly higher in older than in younger patients with RVO (62% [53/86] vs. 38% [15/39], P = 0.016). However, the latter had a significantly higher prevalence of cerebral SVD than their age-matched controls (38% [15/39] vs. 4% [47/1105], P < 0.001). There was no difference in prevalence of cerebral SVD between the central and branch RVO groups (P = 0.478).
Cerebral SVD presented frequently in patients with RVO and was magnified in young patients, suggesting that RVO is a surrogate marker for cerebral SVD.
我们研究了偶然发生视网膜静脉阻塞（RVO）患者的脑小血管疾病（SVD）。
这项回顾性、病例对照观察性试验纳入了125例接受脑磁共振成像（MRI）检查的RVO患者以及1105例年龄匹配的对照者，后者接受了全面的医学访谈和MRI检查。根据年龄（<60岁或≥60岁）和RVO阻塞程度（中央型或分支型），对RVO患者的潜在心血管疾病和MRI表现进行了研究。比较了年轻RVO患者与年龄匹配对照者的潜在心血管疾病特征和MRI表现。还评估了年轻RVO患者的脑血管负担。
RVO患者的平均年龄为63.9±12.1岁，主要潜在疾病为高血压（72/125，58%）。年龄较大的RVO组高血压病史更长，吸烟史更少。RVO组脑SVD的患病率为54%（68/125），年龄较大的RVO患者显著高于年龄较小的患者（62%[53/86]对38%[15/39]，P = 0.016）。然而，后者脑SVD的患病率显著高于其年龄匹配的对照者（38%[15/39]对4%[47/1105]，P < 0.001）。中央型和分支型RVO组之间脑SVD的患病率没有差异（P = 0.478）。
脑SVD在RVO患者中频繁出现，在年轻患者中更为明显，提示RVO是脑SVD的替代标志物。
