Western Sydney University, Brain Neuroplasticity and Rehabilitation Unit (BRAiN-u), School of Science and Health, Penrith, NSW, Australia.
Department of Health Science and Technology, Laboratory for Musculoskeletal Pain and Motor Control, Center for Neuroplasticity and Pain (CNAP), Faculty of Medicine, Aalborg University, Aalborg, Denmark.
Pain Med. 2018 Mar 1;19(3):608-614. doi: 10.1093/pm/pnx099.
To examine the effect of motor activity on the magnitude and duration of altered corticomotor output following experimental muscle pain.
Experimental, pre-post test.
University laboratory.
Twenty healthy individuals.
Participants were randomly allocated to a Rest or Movement group. The Rest group sat quietly without moving for the duration of the experiment. The Movement group repeated a unimanual pattern of five sequential keystrokes as quickly and as accurately as possible immediately following the resolution of pain. Pain was induced into the right extensor carpi radialis brevis muscle by a bolus injection of 0.5 mL hypertonic saline. Corticomotor output was assessed as motor evoked potentials in response to transcranial magnetic stimulation before, immediately after, and at 10, 20, and 30 minutes following pain resolution. Pain intensity was recorded every 30 seconds using an 11-point numerical rating scale.
There was no difference in peak pain intensity (P < 0.09) or duration (P < 0.2) between groups. Corticomotor output was reduced in both groups (P < 0.002) at 10 minutes (P < 0.002), 20 minutes (P < 0.02), and 30 minutes (P < 0.037) following the resolution of pain relative to baseline. There was no difference between groups at any time point.
Performance of motor activity immediately following the resolution of acute muscle pain did not alter the magnitude or duration of corticomotor depression. Understanding corticomotor depression in the postpain period and what factors promote recovery has relevance for clinical pain syndromes where ongoing motor dysfunction, in the absence of pain, may predispose to symptom persistence or recurrence.
研究运动活动对实验性肌肉疼痛后皮质运动输出的幅度和持续时间的影响。
实验，前后测试。
大学实验室。
20 名健康个体。
参与者被随机分配到休息或运动组。休息组在实验过程中安静地坐着不动。运动组在疼痛缓解后立即重复一个单手的连续五次按键模式，尽可能快且准确。通过向右侧伸腕短肌单次推注 0.5ml 高渗盐水诱导疼痛。在疼痛缓解后即刻、10 分钟、20 分钟和 30 分钟，通过经颅磁刺激评估皮质运动输出作为运动诱发电位。使用 11 点数字评分量表每 30 秒记录一次疼痛强度。
两组的峰值疼痛强度（P<0.09）或持续时间（P<0.2）均无差异。两组在疼痛缓解后 10 分钟（P<0.002）、20 分钟（P<0.02）和 30 分钟（P<0.037）时皮质运动输出均降低，与基线相比。在任何时间点，两组之间均无差异。
在急性肌肉疼痛缓解后立即进行运动活动不会改变皮质运动抑制的幅度或持续时间。了解疼痛后时期的皮质运动抑制以及哪些因素促进恢复，对于持续存在运动功能障碍而无疼痛的临床疼痛综合征具有重要意义，因为在这种情况下，症状的持续存在或复发可能会导致运动功能障碍。
