Evers Josef, Schreiber George B, Taborski Uwe
Octapharma Plasma, Plasmazentrum Aachen, Aachen - Germany.
Plasma Protein Therapeutics Association (PPTA), Annapolis - USA.
Int J Artif Organs. 2017 May 29;40(5):230-233. doi: 10.5301/ijao.5000589. Epub 2017 May 19.
This paper reports our experience in 50 cases with severe hypotensive reactions at plasma donations (synonymous with donor plasmaphereses).
Plasma donors who developed a severe acute hypotensive reaction at donor plasmapheresis, and were treated by placing the donor in the Trendelenburg position and rapid infusion of 1,000 mL saline were investigated. Plasmaphereses were performed with the Haemonetics® plasma collecting system 2 (PCS2). The results were analyzed using Excel.
We observed 50 severe hypotensive reactions in plasma donors. The average systolic and diastolic blood pressures (SBP, DBP) were 128/75 mmHg - and heart rates were 78 beats/min (B/M) before plasmaphereses, 83/56 mmHg - 60 B/M at the event, and after treatment 119/71 mmHg - 69 B/M at the time of discharge. The volume of collected plasma was 602 ± 240 mL including anticoagulant (AC). The time until the event was 45 ± 20 minutes. With treatment 49 ± 18 minutes after the event all plasma donors had normal blood pressures and heart rates and could safely leave the center.
Treatment by placing the donor in the Trendelenburg position and rapid infusion of 1,000 mL saline appears to be an effective procedure for resolving severe acute hypotension associated with donor plasmaphereses.
本文报告了我们在50例血浆捐献（等同于供体血浆置换）时发生严重低血压反应的经验。
对在供体血浆置换时发生严重急性低血压反应，并通过将供体置于头低脚高位和快速输注1000 mL生理盐水进行治疗的血浆捐献者进行了调查。血浆置换使用Haemonetics®血浆采集系统2（PCS2）进行。结果使用Excel进行分析。
我们观察到50例血浆捐献者发生严重低血压反应。血浆置换前平均收缩压和舒张压（SBP，DBP）为128/75 mmHg，心率为78次/分钟（B/M）；事件发生时为83/56 mmHg，60 B/M；治疗后出院时为119/71 mmHg，69 B/M。采集的血浆量（包括抗凝剂（AC））为602±240 mL。事件发生前的时间为45±20分钟。事件发生后49±18分钟进行治疗，所有血浆捐献者血压和心率均恢复正常，可安全离开中心。
将供体置于头低脚高位并快速输注1000 mL生理盐水的治疗方法似乎是解决与供体血浆置换相关的严重急性低血压的有效方法。
