Gault M H, Vasdev S, Longerich L, Johnson E, Farid N, Legal Y, Prabhakaran V, Fine A
Department of Medicine, General Hospital, St. John's, Nfld., Canada.
Clin Physiol Biochem. 1988;6(5):253-61.
Digitalis-like factors (DLF) were assayed on plasma collected serially using antibody to digoxin: (1) after intravenous ACTH (n = 3 patients) and (2) after 0.15 U/kg crystalline insulin, 50 micrograms gonadotropin-releasing hormone and 0.2 mg thyrotropin-releasing hormone (n = 7) as a combined pituitary function test. Patients had either hypothalamic-pituitary or ovarian problems. Mean values for DLF rose fourfold after ACTH, and by a factor of 2.3 with the combined pituitary function test. DLF rose at least 50% in all 10 subjects. In 3 dogs, adrenal vein values for DLF were on average more than double values in either adrenal artery or lower vena cava. These results suggest that certain DLFs have an adrenal origin.
使用地高辛抗体对连续采集的血浆样本进行洋地黄样因子（DLF）检测：（1）静脉注射促肾上腺皮质激素后（3例患者），以及（2）作为联合垂体功能试验，在注射0.15 U/kg结晶胰岛素、50微克促性腺激素释放激素和0.2毫克促甲状腺激素释放激素后（7例患者）。患者存在下丘脑-垂体或卵巢问题。促肾上腺皮质激素注射后，DLF的平均值增加了四倍，联合垂体功能试验后增加了2.3倍。所有10名受试者的DLF至少升高了50%。在3只犬中，肾上腺静脉中DLF的平均值平均比肾上腺动脉或下腔静脉中的值高出一倍以上。这些结果表明，某些DLF起源于肾上腺。
