麻醉中的药物基因组学

Pharmacogenomics in Anesthesia.

作者信息

Saba Ramsey, Kaye Alan D, Urman Richard D

机构信息

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

Department of Anesthesiology and Pain Medicine, LSU Health Science Center, Louisiana State University School of Medicine, 1542 Tulane Avenue, Room 659, New Orleans, LA 70112, USA.

出版信息

Anesthesiol Clin. 2017 Jun;35(2):285-294. doi: 10.1016/j.anclin.2017.01.014.

DOI:10.1016/j.anclin.2017.01.014

PMID:28526149

Abstract

A significant number of commonly administered medications in anesthesia show wide clinical interpatient variability. Some of these include neuromuscular blockers, opioids, local anesthetics, and inhalation anesthetics. Individual genetic makeup may account for and predict cardiovascular outcomes after cardiac surgery. These interactions can manifest at any point in the perioperative period and may also only affect a specific system. A better understanding of pharmacogenomics will allow for more individually tailored anesthetics and may ultimately lead to better outcomes, decreased hospital stays, and improved patient satisfaction.

摘要

麻醉中大量常用药物在临床患者间表现出很大的变异性。其中一些药物包括神经肌肉阻滞剂、阿片类药物、局部麻醉药和吸入麻醉药。个体基因构成可能解释并预测心脏手术后的心血管结局。这些相互作用可在围手术期的任何时间显现，也可能仅影响特定系统。对药物基因组学有更深入的了解将有助于制定更个性化的麻醉方案，并最终可能带来更好的治疗效果、缩短住院时间以及提高患者满意度。