Kaye Alan D, Cornett Elyse M, Chalabi John, Naim Natale Z, Novitch Matthew B, Creel Justin B, Jhita Preya, Trang Thomas N, Paetzold Jacquelyn R, Darensburg Nicholas, Beakley Burton D, Urman Richard D
Department of Anesthesiology and Pharmacology, Anesthesiology Services, University Medical Center Hospital, LSU School of Medicine T6M5, 1542 Tulane Avenue, Room 656, New Orleans, LA 70112, USA.
Department of Anesthesiology, LSU School of Medicine, 1501 Kings Highway, P.O. Box 33932, Shreveport, LA 71130-3932, USA.
Anesthesiol Clin. 2017 Jun;35(2):e41-e54. doi: 10.1016/j.anclin.2017.01.003.
Postoperative nausea and vomiting (PONV) is associated with delayed recovery and dissatisfaction after surgical procedures. A key component to management is identifying risk factors and high-risk populations. Advances in pharmacologic therapeutics have resulted in agents targeting different pathways associated with the mediation of nausea and vomiting. This review focuses on these agents and the clinical aspects of their use in patients postoperatively. Combination therapies are reviewed, and studies demonstrate that when 2 or more antiemetic agents acting on different receptors are used, an overall improved efficacy is demonstrated when compared with a single agent alone in patients.
