饮食习惯与中年人群结直肠癌风险：一项基于大样本的前瞻性队列研究。

Dietary patterns and colorectal cancer risk in middle-aged adults: A large population-based prospective cohort study.

机构信息

Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Institute of Environmental Medicine, Seoul National University Medical Research Center, 102 Daehak-ro, Jongro-gu, Seoul 03080, South Korea; Department of Preventive Medicine, Seoul National University College of Medicine, 102 Daehak-ro, Jongro-gu, Seoul 03080, South Korea.

Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

出版信息

Clin Nutr. 2018 Jun;37(3):1019-1026. doi: 10.1016/j.clnu.2017.04.015. Epub 2017 May 5.

DOI:10.1016/j.clnu.2017.04.015

PMID:28526274

Abstract

BACKGROUND & AIMS: A finding between dietary pattern and cancer may provide visions beyond the assessment of individual foods or nutrients. We examined the influence of dietary pattern with colorectal cancer (CRC) among a Japanese population.

METHODS

A total of 93,062 subjects (43,591 men, 49,471 women) who participated in the Japan Public Health Center-based Prospective Study were followed from 1995-1998 to the end of 2012, during which 2482 cases of CRC (1514 men, 968 women) were newly identified. Dietary data was obtained from a validated food-frequency questionnaire between 1995 and 1998.

RESULTS

Three dietary pattern was derived from principal components factor: prudent, westernized, and traditional pattern. After controlled for potential confounders, the prudent pattern showed a decreased association of CRC risk in men (HR for highest quintile vs lowest: 0.85; 95% CI: 0.72-1.00; P trend <0.05), slightly more strongly with distal colon cancer (P trend <0.05); but an increased risk of rectal cancer in women (P trend <0.05). The westernized pattern showed a significant positive linear trend for colon (P trend <0.05) and distal cancer (P trend <0.05) in women. There was no apparent association of traditional Japanese dietary pattern on the overall or any specific sites risk of CRC.

CONCLUSIONS

A prudent dietary pattern showed an inverse association with CRC risk in men, and a westernized pattern was related with a higher risk of colon and distal cancer in women.

摘要

背景与目的

饮食模式与癌症之间的关联可能提供超越个体食物或营养素评估的新视角。我们在日本人群中研究了饮食模式与结直肠癌（CRC）之间的关系。

方法

共有 93062 名参与者（43591 名男性，49471 名女性）参加了日本公共卫生中心前瞻性研究，随访时间从 1995 年至 1998 年至 2012 年底，在此期间新确诊了 2482 例 CRC（1514 名男性，968 名女性）。1995 年至 1998 年期间通过验证后的食物频率问卷获取饮食数据。

结果

通过主成分因子分析得出三种饮食模式：谨慎模式、西式模式和传统模式。在控制了潜在混杂因素后，谨慎模式显示与男性 CRC 风险呈负相关（最高五分位与最低五分位的 HR：0.85；95%CI：0.72-1.00；P 趋势 <0.05），与远端结肠癌的相关性更强（P 趋势 <0.05）；但女性直肠癌的风险增加（P 趋势 <0.05）。西式模式显示女性结肠癌（P 趋势 <0.05）和远端结肠癌（P 趋势 <0.05）呈显著正线性趋势。传统日本饮食模式与 CRC 风险的总体或任何特定部位均无明显关联。