Decher Niels, Kiper Aytug K, Rinné Susanne
Institute for Physiology and Pathophysiology, AG Vegetative Physiology, Deutschhausstrasse 1-2, 35037 Marburg, Germany.
Institute for Physiology and Pathophysiology, AG Vegetative Physiology, Deutschhausstrasse 1-2, 35037 Marburg, Germany.
Prog Biophys Mol Biol. 2017 Nov;130(Pt B):223-232. doi: 10.1016/j.pbiomolbio.2017.05.005. Epub 2017 May 16.
This review focuses on the role and the molecular candidates of the cardiac stretch-activated potassium current (SAK). The functional properties of the two-pore domain potassium (K) channel TREK-1, a major candidate for the cardiac SAK, are analyzed and the molecular mechanism of stretch-activation in K potassium channels is discussed. Furthermore, the functional modulation of TREK-1 by different cardiac interaction partners, as well as evidence for the functional role of the stretch-dependent TREK-1 and its putative subunits in the heart is reviewed. In addition, we summarize the recent evidence that TREK-1 is involved in the pathogenesis of human cardiac arrhythmias.
本综述聚焦于心脏牵张激活钾电流（SAK）的作用及分子候选物。分析了双孔域钾（K）通道TREK-1作为心脏SAK主要候选物的功能特性，并讨论了钾通道牵张激活的分子机制。此外，还综述了不同心脏相互作用伙伴对TREK-1的功能调节，以及牵张依赖性TREK-1及其假定亚基在心脏中的功能作用证据。另外，我们总结了TREK-1参与人类心律失常发病机制的最新证据。
