Aranyi C, Vana S N, Bradof J N, Sherwood R
IIT Research Institute, Chicago, IL 60616.
J Appl Toxicol. 1988 Dec;8(6):393-8.
The effects of inhalation of red phosphorus/butyl rubber (RP/BR) used as an obscurant smoke in tactical environments was examined. Sprague-Dawley male rats were exposed to 1000 mg/m3 of RP/BR for 3.5 h in single exposures, while in subsequent intermediate and subchronic studies the animals were exposed to concentrations ranging from 300 to 1200 mg/m3 for 2.25 h/day, 4 consecutive days/week for 4 and 13 weeks, respectively. Pulmonary bactericidal activity to inhaled [35S]-Klebsiella pneumoniae was depressed after the acute and the 13-week subchronic exposures but was unchanged after the 4-week exposures. The pulmonary free cells collected by lavage showed decreasing trends in total numbers, increased ATP levels and decreased ectoenzyme activity for 5'-nucleotidase after most of the exposures. Mild-to-moderate-to-severe terminal broncheolar fibrosis was observed in all rats after 4- and 13-week exposures to greater than or equal to 750 mg/m3 of RP/BR. The severity of the lesions increased with the severity of the exposure conditions. Except for the fibrosis, most changes were reversible.
研究了在战术环境中用作遮蔽烟雾的红磷/丁基橡胶（RP/BR）吸入的影响。将Sprague-Dawley雄性大鼠单次暴露于1000 mg/m³的RP/BR中3.5小时，而在随后的中期和亚慢性研究中，动物分别暴露于300至1200 mg/m³的浓度下，每天2.25小时，每周连续4天，持续4周和13周。急性和13周亚慢性暴露后，对吸入的[35S] - 肺炎克雷伯菌的肺部杀菌活性降低，但4周暴露后无变化。大多数暴露后，通过灌洗收集的肺部游离细胞总数呈下降趋势，ATP水平升高，5'-核苷酸酶的外切酶活性降低。在暴露于大于或等于750 mg/m³的RP/BR 4周和13周后，所有大鼠均观察到轻度至中度至重度终末细支气管纤维化。病变的严重程度随暴露条件的严重程度而增加。除纤维化外，大多数变化是可逆的。
