绝经后女性腰椎骨密度与血清尿酸之间的关联：一项针对中国健康人群的横断面研究。

Association between lumbar bone mineral density and serum uric acid in postmenopausal women: a cross-sectional study of healthy Chinese population.

作者信息

Han Wen, Bai Xiaojuan, Wang Nan, Han Lulu, Sun Xuefeng, Chen Xiangmei

机构信息

Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, China.

Department of Kidney, General Hospital of Chinese People's Liberation Army, Beijing, China.

出版信息

Arch Osteoporos. 2017 Dec;12(1):50. doi: 10.1007/s11657-017-0345-0. Epub 2017 May 19.

DOI:10.1007/s11657-017-0345-0

PMID:28527105

Abstract

UNLABELLED

Partial correlation and regression analyses were used in this study. We showed that there is a linear relationship between bone mineral density and serum uric acid within the normal physiologic range, and higher serum uric acid levels had a protective effect on bone loss in postmenopausal osteoporosis.

PURPOSE

The significance of the relationship between lumbar bone mineral density BMD) and serum uric acid (SUA) levels is unclear. The aims of this study were to investigate on a population-level the association between lumbar BMD and SUA within the normal physiologic range and to determine whether SUA plays a protective role in bone loss in healthy postmenopausal Chinese women.

METHODS

This was a community-based cross-sectional study involving 390 healthy postmenopausal women, 47-89 years of age, conducted in Shenyang, China. The BMD was measured at the lumbar spine using dual-energy X-ray absorptiometry (DXA). The SUA levels were obtained at each DXA visit. Partial correlation and regression analyses were applied to determine the associations.

RESULTS

The SUA levels were significantly different between the normal BMD, osteopenia, and osteoporosis groups. The lumbar BMD was positively correlated with SUA in postmenopausal women after adjustment for age (r = 0.212). After adjustment for age, body mass index, systolic blood pressure, diastolic blood pressure, hip circumference, cigarette smoking, alcohol consumption, milk intake, physical exercise, fracture history, total protein, total bilirubin, triglycerides, total cholesterol, high-density lipoprotein cholesterol, fasting blood glucose, serum calcium, and estimated glomerular filtration rate, the lumbar BMD was associated with SUA and the odds ratio of the third SUA quartile was 0.408 (95%CI, 0.198-0.841, P = 0.015), compared to the first quartile of SUA levels.

CONCLUSION

The lumbar BMD was linearly associated with SUA levels within the normal physiologic range of postmenopausal women. Higher SUA levels had a protective effect on bone loss in postmenopausal osteoporosis.

摘要

未标注

本研究采用偏相关和回归分析。我们发现，在正常生理范围内，骨密度与血清尿酸之间存在线性关系，且较高的血清尿酸水平对绝经后骨质疏松症的骨质流失具有保护作用。

目的

腰椎骨密度（BMD）与血清尿酸（SUA）水平之间关系的意义尚不清楚。本研究的目的是在人群水平上调查正常生理范围内腰椎BMD与SUA之间的关联，并确定SUA是否对健康绝经后中国女性的骨质流失起保护作用。

方法

这是一项基于社区的横断面研究，在中国沈阳对390名年龄在47 - 89岁的健康绝经后女性进行。使用双能X线吸收法（DXA）测量腰椎的BMD。每次DXA检查时获取SUA水平。应用偏相关和回归分析来确定关联。

结果

正常BMD、骨量减少和骨质疏松组之间的SUA水平存在显著差异。在调整年龄后，绝经后女性的腰椎BMD与SUA呈正相关（r = 0.212）。在调整年龄、体重指数、收缩压、舒张压、臀围、吸烟、饮酒、牛奶摄入量、体育锻炼、骨折史、总蛋白、总胆红素、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、空腹血糖、血清钙和估计肾小球滤过率后，腰椎BMD与SUA相关，与SUA第一四分位数相比，SUA第三四分位数的比值比为0.408（95%CI，0.198 - 0.841，P = 0.015）。