Kamangar Sarfaraz, Badruddin Irfan Anjum, Ameer Ahamad N, Soudagar Manzoor Elahi M, Govindaraju Kalimuthu, Nik-Ghazali N, Salman Ahmed N J, Yunus Khan T M
Department of Mechanical Engineering, University of Malaya, Kuala Lumpur 50603, Malaysia.
Mathematics Department, Faculty of Science, University of Tabuk, Saudi Arabia.
Biomed Mater Eng. 2017;28(3):257-266. doi: 10.3233/BME-171672.
The current study investigates the effect of multi stenosis on the hemodynamic parameters such as wall pressure, velocity and wall shear stress in the realistic left coronary artery. Patients CT scan image data of normal and diseased left coronary artery was chosen for the reconstruction of 3D coronary artery models. The diseased 3D model of left coronary artery shows a narrowing of more than 70% and 80% of area stenosis (AS) at the left main stem (LMS) and left circumflex (LCX) respectively. The results show that the decrease in pressure was found downstream to the stenosis as compared to the coronary artery without stenosis. The maximum pressure drop was noted across the 80% AS at the left circumflex branch. The recirculation zone was also observed immediate to the stenosis and highest wall shear stress was found across the 80% area stenosis. Our analysis provides an insight into the distribution of wall shear stress and pressure drop, thus improving our understanding on the hemodynamics in realistic coronary artery.
本研究调查了多狭窄对真实左冠状动脉中壁压力、速度和壁面剪应力等血流动力学参数的影响。选择正常和病变左冠状动脉的患者CT扫描图像数据来重建三维冠状动脉模型。病变的左冠状动脉三维模型显示，左主干（LMS）和左旋支（LCX）的面积狭窄（AS）分别超过70%和80%。结果表明，与无狭窄的冠状动脉相比，狭窄下游的压力降低。在左旋支80%面积狭窄处观察到最大压力降。在狭窄处紧邻区域也观察到了再循环区，并且在80%面积狭窄处发现了最高的壁面剪应力。我们的分析深入了解了壁面剪应力和压力降的分布，从而增进了我们对真实冠状动脉血流动力学的理解。
