Marais Louise, Zidi Mustapha
Bioengineering, Tissues and Neuroplasticity (BIOTN), EA 7377, Paris-Est Créteil University, Faculty of Medicine, Surgical Research Center, 8 rue du Général Sarrail, 94010 Créteil, France.
J Mech Behav Biomed Mater. 2017 Oct;74:28-34. doi: 10.1016/j.jmbbm.2017.04.029. Epub 2017 May 12.
This paper addresses the mechanical biaxial behavior of degraded arteries obtained by the rat xenograft model. For that, a pressure myograph was used to perform extension-inflation tests on abdominal aortic aneurysms (AAAs). Furthermore, residual stresses in the aneurismal wall were assessed by opening angle tests. Thus, the changes in mechanical behavior between native murine aortas, decellularized guinea pig aortas (the grafts) and degraded aortas (AAAs) were investigated. It was shown that decellularized and degraded aortas exhibited a different mechanical behavior than native murine aortas. Indeed, decellularized aortas presented a marked decrease in circumferential stretch and distensibility compared with native aortas. Moreover, we evidenced an exacerbation of these changes in mechanical behavior for AAAs, which showed the lowest distension and distensibility at 100mmHg. The opening angle test also revealed a complete loss of residual stresses in the degraded arterial wall given the non opening of rings extracted from AAAs.
本文探讨了通过大鼠异种移植模型获得的退化动脉的双轴力学行为。为此，使用压力肌动描记器对腹主动脉瘤（AAA）进行拉伸-膨胀试验。此外，通过开口角度试验评估动脉瘤壁中的残余应力。因此，研究了天然小鼠主动脉、脱细胞豚鼠主动脉（移植物）和退化主动脉（AAA）之间力学行为的变化。结果表明，脱细胞和退化的主动脉表现出与天然小鼠主动脉不同的力学行为。事实上，与天然主动脉相比，脱细胞主动脉的周向拉伸和扩张性明显降低。此外，我们证明了AAA力学行为的这些变化加剧，在100mmHg时表现出最低的扩张和扩张性。开口角度试验还表明，从AAA中提取的环未打开，退化动脉壁中的残余应力完全丧失。
