Pietrzyńska Monika, Czerwiński Michał, Voelkel Adam
Poznań University of Technology, Institute of Chemical Technology and Engineering, ul. Berdychowo 4, Poznań, Poland.
Poznań University of Technology, Institute of Chemical Technology and Engineering, ul. Berdychowo 4, Poznań, Poland.
Eur J Pharm Sci. 2017 Jul 15;105:195-202. doi: 10.1016/j.ejps.2017.05.040. Epub 2017 May 17.
Polymer-ceramic materials based on poly(vinyl alcohol) (PVA) and hydroxyapatite were applied as sorption material in Monolithic In-Needle Extraction (MINE) device. The presented device provides new possibilities for the examination of bisphosphonates affinity for bone and will be a helpful tool in evaluation of potential antiresorptive drugs suitability. A ceramic part of monoliths was prepared by incorporation of hydroxyapatite (HA) into the reaction mixture or by using a soaking method (mineralization of HA on the PVA). The parameters of synthesis conditions were optimized to achieve a monolithic material having the appropriate dimensions after the soaking process enabling placing of the monolithic material inside the needle. Furthermore, the material must have had optimal dimensions after the re-soaking process to fit perfectly to the needle. Among the sixteen monolithic materials, eight of them were selected for further study, and then four of them were selected as a sorbent material for the MINE device. The material properties were examined on the basis of several parameters: swelling ratio, initial mass reversion and initial diameter reversion, mass growth due to the HA formation, and antiresorptive drug sorption. The MINE device might be then used as a tool for examination of interactions between bisphosphonate and bone. The simulated body fluid containing sodium risedronate (RSD) as a standard compound was passed through the MINE device. The obtained device allowed for sorption about 0.38mg of RSD. The desorption process was carried out in five steps allowing insightful analysis. The MINE device turned out to be a helpful tool for determination of the bisphosphonates affinity to the ceramic part of sorbent (hydroxyapatite) and to assess the usefulness of them as antiresorptive drugs in the future.
基于聚乙烯醇（PVA）和羟基磷灰石的聚合物陶瓷材料被用作整体式针内萃取（MINE）装置中的吸附材料。所展示的该装置为研究双膦酸盐对骨的亲和力提供了新的可能性，并且将成为评估潜在抗吸收药物适用性的有用工具。整体材料的陶瓷部分通过将羟基磷灰石（HA）掺入反应混合物中或采用浸泡法（在PVA上使HA矿化）制备。优化合成条件参数，以便在浸泡过程后获得具有合适尺寸的整体材料，从而能够将整体材料放置在针内。此外，在再次浸泡过程后，材料必须具有最佳尺寸以完美适配针。在这16种整体材料中，挑选了8种进行进一步研究，然后其中4种被选作MINE装置的吸附材料。基于几个参数对材料性能进行了检测：溶胀率、初始质量回复率和初始直径回复率、由于HA形成导致的质量增长以及抗吸收药物吸附。然后，MINE装置可作为研究双膦酸盐与骨之间相互作用的工具。将含有利塞膦酸钠（RSD）作为标准化合物的模拟体液通过MINE装置。所获得的装置能够吸附约0.38mg的RSD。解吸过程分五步进行，以便进行深入分析。结果表明，MINE装置是测定双膦酸盐对吸附剂陶瓷部分（羟基磷灰石）亲和力以及评估它们未来作为抗吸收药物有效性的有用工具。
