Kurt-Jones Evelyn A, Orzalli Megan H, Knipe David M
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, 01605, USA.
Division of Gastroenterology, Boston Children's Hospital, Boston, MA, 02115, USA.
Adv Anat Embryol Cell Biol. 2017;223:49-75. doi: 10.1007/978-3-319-53168-7_3.
Innate immune responses play a major role in the control of herpes simplex virus (HSV) infections, and a multiplicity of mechanisms have emerged as a result of human evolution to sense and respond to HSV infections. HSV in turn has evolved a number of ways to evade immune detection and to blunt human innate immune responses. In this review, we summarize the major host innate immune mechanisms and the HSV evasion mechanisms that have evolved. We further discuss how disease can result if this equilibrium between virus and host response is disrupted.
先天免疫反应在单纯疱疹病毒（HSV）感染的控制中起主要作用，由于人类进化，出现了多种感知和应对HSV感染的机制。反过来，HSV也进化出了多种逃避免疫检测和削弱人类先天免疫反应的方法。在这篇综述中，我们总结了主要的宿主先天免疫机制以及已进化出的HSV逃避机制。我们还进一步讨论了如果病毒与宿主反应之间的这种平衡被打破会如何导致疾病。
