Rosenberg N, Witte O N
Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111.
Adv Virus Res. 1988;35:39-81. doi: 10.1016/s0065-3527(08)60708-3.
The precision of molecular biology has allowed a better definition of the components of the Abelson system. We know the gene structures and gene products for the cellular and viral forms of this family of related tyrosine kinases. However, many basic issues first identified in the early biological observations of Abelson, Rabstein, and others remain unanswered. The precise pathway for transformation in biochemical terms remains unknown for Ab-MLV and all of its relatives. Relatively little can be said to explain the preferential growth stimulation for certain hematopoietic cell types by the viral and other altered forms of the oncogene, and no clear insights into the function of the normal cellular forms of the abl oncogene are available. Future progress will certainly depend on the intensive efforts by many workers in the broader field of cellular growth control mechanisms.
分子生物学的精确性使得对阿贝尔森系统的组成部分有了更清晰的定义。我们了解这个相关酪氨酸激酶家族的细胞和病毒形式的基因结构及基因产物。然而，许多最早在阿贝尔森、拉布斯坦等人早期生物学观察中发现的基本问题仍未得到解答。从生化角度来看，Ab-MLV及其所有亲属的精确转化途径仍然未知。对于病毒和癌基因的其他改变形式对某些造血细胞类型的优先生长刺激，能解释的相对较少，并且对于abl癌基因正常细胞形式的功能也没有明确的见解。未来的进展肯定将取决于细胞生长控制机制更广泛领域中许多研究人员的深入努力。
