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踝关节双极新鲜全骨软骨异体移植:它是一种成功的长期解决方案吗?

Bipolar fresh total osteochondral allograft in the ankle: Is it a successful long-term solution?

作者信息

Giannini S, Mazzotti A, Vannini F

机构信息

Istituto Ortopedico Rizzoli, Bologna University, Bologna, Italy.

II Clinic of Orthopaedic and Traumatology, Istituto Ortopedico Rizzoli, Bologna University, Bologna, Italy.

出版信息

Injury. 2017 Jul;48(7):1319-1324. doi: 10.1016/j.injury.2017.05.011. Epub 2017 May 11.

DOI:10.1016/j.injury.2017.05.011
PMID:28529013
Abstract

INTRODUCTION

Severe post-traumatic ankle arthritis poses a reconstructive challenge in young and active patients. Although technically demanding and despite unsolved immunological issues, bipolar fresh total osteochondral allograft (BFTOA) represent an intriguing option to arthrodesis and prosthetic replacement. The purpose of this paper is to evaluate the outcomes of a series of 48 ankle BFTOA at 10 years follow up and to investigate the rate of survival long term.

METHODS

58 patients underwent BFTOA, of these 48 were available for follow up. The allograft was prepared with the help of specifically designed jigs and the surgery was performed using either a lateral or a direct anterior approach. Patients were evaluated clinically and radiographically preoperatively, and at a mean 121±18months of follow-up.

RESULTS

The AOFAS score improved from 31±11 pre operatively, to 65±25 at the last (p<0.0005). Fourteen failures occurred, with 70.8% allograft rate of survival. All the surviving allografts showed a reduction of the ankle joint movement, still associated with a satisfactory clinical result.

CONCLUSION

The use of BFTOA represents an intriguing option to arthrodesis or arthroplasty. A satisfactory clinical result associated to a good movement of the transplanted joint is to be expected up to short-mid-term, overtime. Long term, the range of motion (ROM) is progressively decreased up to spontaneous arthrodesis in some cases, still the joint results pain free and patient's perception is of a well functioning ankle. A deeper knowledge of the immunological behavior of transplanted cartilage is needed in order to improve the durability of this fascinating technique.

摘要

引言

严重创伤后踝关节关节炎给年轻活跃患者的重建带来了挑战。尽管技术要求高且存在未解决的免疫问题,但双极新鲜全骨软骨异体移植术(BFTOA)是一种有吸引力的关节融合术和假体置换替代方案。本文旨在评估48例踝关节BFTOA在10年随访时的结果,并研究其长期生存率。

方法

58例患者接受了BFTOA,其中48例可供随访。异体移植借助专门设计的夹具制备,手术采用外侧或直接前路入路。术前以及平均随访121±18个月时对患者进行临床和影像学评估。

结果

美国足踝外科协会(AOFAS)评分从术前的31±11提高到末次随访时的65±25(p<0.0005)。发生了14例失败,异体移植生存率为70.8%。所有存活的异体移植均显示踝关节活动度降低,但临床结果仍令人满意。

结论

BFTOA的应用对关节融合术或关节成形术来说是一种有吸引力的选择。在中短期内,可预期获得满意的临床结果以及移植关节良好的活动度。长期来看,在某些情况下关节活动范围(ROM)会逐渐减小直至自发融合,但关节仍无痛,患者感觉踝关节功能良好。为提高这项迷人技术的耐久性,需要更深入了解移植软骨的免疫行为。

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