Ezeme Mark Sunday, Uwakwe Richard, Ndukuba Appolos Chidi, Igwe Monday N, Odinka Paul Chigozie, Amadi Kennedy, Obayi Nichodemus O
J Health Care Poor Underserved. 2017;28(2):721-738. doi: 10.1353/hpu.2017.0070.
A significant proportion of patients treated for schizophrenia respond poorly to medication. Few studies have systematically examined the impact of clinical characteristics of patients to antipsychotic response in our environment. The study aimed to identify clinical variables associated with response in patients with schizophrenia. A total of 172 participants diagnosed with schizophrenia, placed on antipsychotics, who presented for the first time to the hospital or have stopped medication in the preceding six months, whose responses were assessed after four to six weeks were studied. Improvement was defined as 20% or greater reduction in PANSS scores. Good response was associated with good medication adherence, good pre-morbid functioning, fewer negative symptoms, less cognitive impairment, absence of co-morbid personality disorder, and short duration of untreated psychosis. Due consideration of the impact of clinical variables could help detect poor responders early, hence avoiding unnecessary exposure to ineffective treatments and their side effects while effective interventions are delayed.
相当一部分接受精神分裂症治疗的患者对药物反应不佳。在我们所处的环境中，很少有研究系统地考察患者临床特征对抗精神病药物反应的影响。该研究旨在确定与精神分裂症患者反应相关的临床变量。共对172名被诊断为精神分裂症、正在服用抗精神病药物、首次入院或在过去六个月内停药且在四至六周后评估其反应的参与者进行了研究。改善定义为阳性和阴性症状评定量表（PANSS）得分降低20%或更多。良好的反应与良好的药物依从性、病前功能良好、阴性症状较少、认知障碍较轻、无共病性人格障碍以及未治疗精神病的持续时间较短有关。充分考虑临床变量的影响有助于早期发现反应不佳者，从而避免不必要地暴露于无效治疗及其副作用，同时延误有效干预。
