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老年颈椎病性脊髓病患者行椎板成形术的手术结果——早期有效手术干预的可能性:一项荟萃分析

Surgical Outcome of Laminoplasty for Cervical Spondylotic Myelopathy in an Elderly Population - Potentiality for Effective Early Surgical Intervention: A Meta-analysis.

作者信息

Takeshima Yasuhiro, Matsuoka Ryuta, Nakagawa Ichiro, Nishimura Fumihiko, Nakase Hiroyuki

机构信息

Department of Neurosurgery, Nara Medical University School of Medicine.

出版信息

Neurol Med Chir (Tokyo). 2017 Jul 15;57(7):366-373. doi: 10.2176/nmc.ra.2016-0302. Epub 2017 May 19.

Abstract

A systematic review and meta-analysis was conducted to determine differences in surgical outcomes of laminoplasty for cervical spondylotic myelopathy (CSM) between elderly and non-elderly patients. PubMed and Google Scholar searches were performed using several key words and phrases related to cervical laminoplasty in elderly populations. Included studies were written in English, addressed laminoplasty for cervical spondylotic myelopathy, and evaluated outcomes of the treatment. Statistical analysis was performed using a random-effect model. The heterogeneity of the studies was assessed using Cochran's Q statistic and I statistic, and a funnel plot was constructed to evaluate publication bias. The search initially identified 255 articles on this topic. Nine clinical studies that met all inclusion criteria were included in the meta-analysis. A total of 1817 patients in these studies underwent cervical laminoplasty. Elderly patients had lower preoperative and postoperative Japanese Orthopedic Association (JOA) scores, and lower recovery rates based on JOA scores. Shorter operation times and reductions in intraoperative blood loss were found in the elderly group compared to the non-elderly group. The incidence of C5 palsy was not different between these groups. We here report the differences in surgical outcomes of laminoplasty for CSM through systematic review and meta-analysis. This report found poor surgical outcomes and lower preoperative JOA scores in elderly patients. Therefore, early surgical intervention may be recommended in elderly patients with CSM.

摘要

进行了一项系统评价和荟萃分析,以确定老年和非老年患者脊髓型颈椎病(CSM)椎板成形术手术结果的差异。使用与老年人群颈椎椎板成形术相关的几个关键词和短语在PubMed和谷歌学术上进行检索。纳入的研究用英文撰写,涉及脊髓型颈椎病的椎板成形术,并评估了治疗结果。采用随机效应模型进行统计分析。使用Cochran's Q统计量和I统计量评估研究的异质性,并构建漏斗图以评估发表偏倚。检索最初识别出255篇关于该主题的文章。九项符合所有纳入标准的临床研究被纳入荟萃分析。这些研究中共有1817例患者接受了颈椎椎板成形术。老年患者术前和术后的日本骨科协会(JOA)评分较低,基于JOA评分的恢复率也较低。与非老年组相比,老年组的手术时间更短,术中失血量减少。两组之间C5麻痹的发生率没有差异。我们通过系统评价和荟萃分析报告了脊髓型颈椎病椎板成形术手术结果的差异。本报告发现老年患者手术结果较差,术前JOA评分较低。因此,对于脊髓型颈椎病老年患者,可能建议早期手术干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9a6/5566709/fbfc20fb0ee9/nmc-57-366-g1.jpg

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