自噬的药理学调节：治疗潜力与持续存在的障碍
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
作者信息
Galluzzi Lorenzo, Bravo-San Pedro José Manuel, Levine Beth, Green Douglas R, Kroemer Guido
机构信息
Department of Radiation Oncology, Weill Cornell Medical College, New York, New York 10065, USA.
Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris 75006, France.
出版信息
Nat Rev Drug Discov. 2017 Jul;16(7):487-511. doi: 10.1038/nrd.2017.22. Epub 2017 May 19.
Abstract
Autophagy is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Accordingly, alterations in autophagy have been linked to clinically relevant conditions as diverse as cancer, neurodegeneration and cardiac disorders. Throughout the past decade, autophagy has attracted considerable attention as a target for the development of novel therapeutics. However, such efforts have not yet generated clinically viable interventions. In this Review, we discuss the therapeutic potential of autophagy modulators, analyse the obstacles that have limited their development and propose strategies that may unlock the full therapeutic potential of autophagy modulation in the clinic.
摘要
自噬对于在生理和病理情况下维持机体稳态至关重要。因此，自噬的改变已与癌症、神经退行性变和心脏疾病等多种临床相关病症联系起来。在过去十年中，自噬作为新型治疗药物开发的靶点已引起了相当大的关注。然而，这些努力尚未产生临床上可行的干预措施。在本综述中，我们讨论了自噬调节剂的治疗潜力，分析了限制其发展的障碍，并提出了可能在临床上释放自噬调节全部治疗潜力的策略。
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