Zhang Dongli, Liu Xiaoming, Fan Conghai, Chen Jiao
Department of Neurology, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
Oncol Lett. 2017 May;13(5):2881-2885. doi: 10.3892/ol.2017.5812. Epub 2017 Mar 6.
Astrocytomas (gliomas) are the most common primary brain tumors among adults and second most frequent neoplasm among children. New ideas and novel approaches are being explored world over with aim to devise better management strategeies for this deadly pathological state. We searched the electronic database PubMed for pre-clinical as well as clinical controlled trials reporting importance of various therapeutic drugs against gliomas. It was observed clearly that this approach of using therapeutic drugs is clearly evolving and has been observed to be promising future therapeutic avenue against gliomas. The searched literature on whole revealed that although gliomas are treated aggressively with surgery, chemotherapy and radiation, treatment resistance, drug toxicity and poor response rates among pediatric glioma patients, continue to drive the need to discover new and more effective chemotherapeutic agents. The present review is focused on the latest updates in therapeutic drugs against gliomas in pediatric patients. The important chemo-therapeutics discussed in this review included alkylating agents like temoxolomide, derivatives of platinum, nitrosoureas, topoisomerases, angiogenesis inhibitors and cytomegalovirus as therapeutic agents.
星形细胞瘤（胶质瘤）是成人中最常见的原发性脑肿瘤，在儿童中是第二常见的肿瘤。世界各地都在探索新的理念和新颖的方法，旨在为这种致命的病理状态设计出更好的治疗策略。我们在电子数据库PubMed中搜索了关于各种治疗药物对胶质瘤重要性的临床前和临床对照试验。可以清楚地观察到，使用治疗药物的这种方法正在明显发展，并且已被视为对抗胶质瘤有前景的未来治疗途径。搜索到的全部文献表明，尽管胶质瘤通过手术、化疗和放疗进行积极治疗，但小儿胶质瘤患者中的治疗耐药性、药物毒性和低反应率，持续推动着发现新的、更有效的化疗药物的需求。本综述聚焦于小儿患者抗胶质瘤治疗药物的最新进展。本综述中讨论的重要化疗药物包括替莫唑胺等烷化剂、铂衍生物、亚硝基脲、拓扑异构酶、血管生成抑制剂和作为治疗剂的巨细胞病毒。
