环磷酸腺苷（cAMP）依赖性蛋白磷酸化参与了与真涡虫神经元内源性细胞钙相关的钾电流激活过程。
Cyclic AMP-dependent protein phosphorylation is involved in activation of the potassium current associated with endogenous cellular calcium in Euhadra neurons.
作者信息
Onozuka M, Imai S, Kubo K, Deura S, Nishiyama K, Ozono S
机构信息
Department of Anatomy, Gifu University School of Medicine, Japan.
出版信息
Brain Res. 1988 Nov 15;473(2):401-5. doi: 10.1016/0006-8993(88)90875-x.
PMID:2852988
Abstract
Intracellular injection of the catalytic subunit of cAMP-dependent protein kinase stimulated the outward potassium current associated with endogenous cellular Ca2+ which were abolished by either caffeine or cAMP-dependent protein kinase inhibitor. The principal action of this kinase in current activation may be to release calcium from the intracellular reservoir.
摘要
向细胞内注射环磷酸腺苷（cAMP）依赖性蛋白激酶的催化亚基，可刺激与内源性细胞Ca2+相关的外向钾电流，而咖啡因或cAMP依赖性蛋白激酶抑制剂均可消除该电流。这种激酶在电流激活中的主要作用可能是从细胞内储存库释放钙。
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