Zuriaga Maria A, Fuster Jose J, Gokce Noyan, Walsh Kenneth
Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
Cardiovascular Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.
Front Cardiovasc Med. 2017 May 5;4:27. doi: 10.3389/fcvm.2017.00027. eCollection 2017.
Visceral adiposity is much more strongly associated with cardiometabolic disease in humans than subcutaneous adiposity. Browning, the appearance of brown-like adipocytes in the white adipose tissue (WAT), has been shown to protect mice against metabolic dysfunction, suggesting the possibility of new therapeutic approaches to treat obesity and type 2 diabetes. In mice, subcutaneous WAT depots express higher levels of browning genes when compared with visceral WAT, further suggesting that differences in WAT browning could contribute to the differences in the pathogenicity of the two depots. However, the expression of browning genes in different WAT depots of human has not been characterized. Here, it is shown that the expression of browning genes is higher in visceral than in subcutaneous WAT in humans, a pattern that is opposite to what is observed in mice. These results suggest that caution should be applied in extrapolating the results of murine browning gene expression studies to human pathophysiology.
在内脏脂肪与皮下脂肪相比，内脏脂肪在人类中与心脏代谢疾病的关联更为紧密。褐色化，即白色脂肪组织（WAT）中出现类似褐色的脂肪细胞，已被证明可保护小鼠免受代谢功能障碍的影响，这表明有可能采用新的治疗方法来治疗肥胖症和2型糖尿病。在小鼠中，与内脏WAT相比，皮下WAT库中褐色化基因的表达水平更高，这进一步表明WAT褐色化的差异可能导致这两个库致病性的差异。然而，人类不同WAT库中褐色化基因的表达尚未得到表征。在此研究中发现，人类内脏WAT中褐色化基因的表达高于皮下WAT，这一模式与在小鼠中观察到的情况相反。这些结果表明，在将小鼠褐色化基因表达研究的结果外推至人类病理生理学情况时应谨慎。
