Habib Sonia, Rishpon Shmuel, Grotto Itamar, Afek Arnon
Haifa District Health Office.
School of Public Health, Haifa University.
Harefuah. 2017 Jan;156(1):4-7.
Seasonal influenza is a significant disease affecting public health due to substantial morbidity and mortality and a high economic burden. in view of its high propensity for genetic mutations, the virus can easily evade preexisting immunity acquired from prior exposure to it, thereby causing severe seasonal epidemics. Influenza vaccination has been shown to be safe and effective. In many countries, including Israel, it is recommended to all members of the population aged 6 months and older, especially those with a higher risk of developing severe complications. Its adverse effects are mostly minimal, local and systemic. No evidence-based relationship between the vaccination and neurological syndromes was found. Infected health care workers (HCWs) may transmit influenza to patients, many of whom have serious underlying conditions that increase their risk of complications. Therefore, influenza vaccination among HCWs is recommended in the United States and in >40 other countries including Israel. In spite of that, the vaccination coverage rates remain low in Israel and in many countries. The reasons include low levels of awareness to the disease severity, to the safety and effectiveness of the vaccine and low levels of trust in authorities. The effectiveness and safety of the vaccine in preventing influenza among the recipients is well documented. High quality evidence on the effectiveness of the vaccine in preventing the disease among patients and family members of HCWs who receive the vaccine is limited. However, combining the existing evidence and the clear biological plausibility lead to the conclusion that the recommendation for vaccinating health care workers against influenza to protect patients is a well-based policy. This is the policy of the WHO, CDC and health authorities in most developed countries. The Ministry of Health in Israel will continue to promote programs to increase vaccine compliance rates among HCWs and to define the uptake of vaccination as a moral duty.
季节性流感是一种影响公众健康的重要疾病,因其会导致大量发病和死亡,并带来高昂的经济负担。鉴于其极易发生基因突变,该病毒能够轻易逃避先前接触所获得的既有免疫力,从而引发严重的季节性流行。流感疫苗已被证明是安全有效的。在包括以色列在内的许多国家,建议6个月及以上的所有人群接种,尤其是那些发生严重并发症风险较高的人群。其不良反应大多轻微,包括局部和全身反应。未发现疫苗接种与神经综合征之间存在基于证据的关联。受感染的医护人员可能会将流感传播给患者,其中许多患者有严重的基础疾病,这增加了他们发生并发症的风险。因此,美国以及包括以色列在内的其他40多个国家都建议医护人员接种流感疫苗。尽管如此,以色列和许多国家的疫苗接种覆盖率仍然很低。原因包括对疾病严重性、疫苗安全性和有效性的认识水平较低,以及对当局的信任度较低。疫苗在接种者中预防流感的有效性和安全性已有充分记录。关于疫苗在预防接种疫苗的医护人员的患者和家庭成员感染疾病方面有效性的高质量证据有限。然而,综合现有证据和明确的生物学合理性可得出结论,建议医护人员接种流感疫苗以保护患者是一项有充分依据的政策。这是世界卫生组织、美国疾病控制与预防中心以及大多数发达国家卫生当局的政策。以色列卫生部将继续推动各项计划,以提高医护人员的疫苗接种率,并将接种疫苗定义为一项道德责任。