State Key Laboratory of Food Science and Technology, Jiangnan University, 214122 Wuxi, China; School of Food Science and Technology, Jiangnan University, 214122 Wuxi, China.
State Key Laboratory of Food Science and Technology, Jiangnan University, 214122 Wuxi, China.
Food Chem. 2017 Oct 15;233:151-158. doi: 10.1016/j.foodchem.2017.04.080. Epub 2017 Apr 18.
An efficient strategy for the synthesis of high-purity lactulose through chemical isomerization of lactose was developed using recyclable catalyst sodium aluminate. Maximum yield of 85.45±1.79% was obtained from 35% (w/v) of lactose using a 1:1M ratio of NaAlO-lactose after reaction at 60°C and pH 12 for 50min, with a purity ratio (Pu) of approximately 95%. Al(OH) precipitation from lactulose syrup through pH adjustment showing a superior decolorizing efficiency was implemented, which simplified the removal of catalyst and provided a convenient approach to achieve catalyst recovery. After dilution by 5 folds, nearly 98.5% of catalyst was removed through centrifugation and 85.50±1.81% of lactulose was recovered. Modified recycle use of catalyst without lactulose loss was carried out, after five consecutive recycles, total yield of lactulose (TY) and new yield of lactulose (NY) were of 80.44±1.05% and 73.87±0.50%, respectively, reflecting a high stability by using this recyclable methodology.
开发了一种通过化学异构化乳糖来合成高纯度半乳糖的有效策略，使用的是可回收催化剂偏铝酸钠。在 60°C 和 pH 12 下反应 50min 后，用 1:1M 的 NaAlO-乳糖比例，从 35%（w/v）的乳糖中获得了 85.45±1.79%的最大产率，纯度比（Pu）约为 95%。通过调整 pH 值从半乳糖糖浆中沉淀出的 Al(OH)，显示出优异的脱色效率，这简化了催化剂的去除过程，并提供了一种方便的方法来实现催化剂的回收。稀释 5 倍后，通过离心去除了近 98.5%的催化剂，回收了 85.50±1.81%的半乳糖。经过五次连续循环，没有乳糖损失的催化剂进行了改良的循环使用，乳糖的总产率（TY）和新产率（NY）分别为 80.44±1.05%和 73.87±0.50%，这表明使用这种可回收方法具有很高的稳定性。
