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阿片类药物成瘾中阿片类激动剂的使用和滥用。

Use and misuse of opioid agonists in opioid addiction.

机构信息

Connecticut Valley Hospital, Middletown, CT, USA.

Quinnipiac University, Hamden, CT, USA.

出版信息

Cleve Clin J Med. 2017 May;84(5):377-384. doi: 10.3949/ccjm.84a.16091.

DOI:10.3949/ccjm.84a.16091
PMID:28530896
Abstract

Although methadone (an opioid agonist) and buprenorphine (a partial opioid agonist) have evidence to support their use in treating opioid use disorder, they remain misunderstood and underutilized. In this article, we outline the risks and benefits of using these drugs as maintenance therapy in opioid-dependent patients.

摘要

虽然美沙酮(阿片类激动剂)和丁丙诺啡(部分阿片类激动剂)有证据支持其用于治疗阿片类药物使用障碍,但它们仍然被误解和未充分利用。在本文中,我们概述了在阿片类药物依赖患者中使用这些药物作为维持治疗的风险和益处。

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Use and misuse of opioid agonists in opioid addiction.阿片类药物成瘾中阿片类激动剂的使用和滥用。
Cleve Clin J Med. 2017 May;84(5):377-384. doi: 10.3949/ccjm.84a.16091.
2
Neonatal outcomes following in utero exposure to methadone or buprenorphine: a National Cohort Study of opioid-agonist treatment of Pregnant Women in Norway from 1996 to 2009.挪威 1996 年至 2009 年接受阿片类激动剂治疗的孕妇的全国队列研究:子宫内暴露于美沙酮或丁丙诺啡后新生儿结局。
Drug Alcohol Depend. 2013 Jan 1;127(1-3):200-6. doi: 10.1016/j.drugalcdep.2012.07.001. Epub 2012 Jul 25.
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Maintenance medication for opiate addiction: the foundation of recovery.阿片类药物成瘾维持治疗药物:康复的基础。
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Methadone and buprenorphine treatments in patients with schizophrenia.精神分裂症患者的美沙酮和丁丙诺啡治疗
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Expanding Treatment Opportunities for Hospitalized Patients with Opioid Use Disorders.为患有阿片类物质使用障碍的住院患者扩大治疗机会。
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Treatment of opioid dependence in the setting of pregnancy.妊娠期阿片类药物依赖的治疗。
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Co-morbid pain and opioid addiction: long term effect of opioid maintenance on acute pain.共病疼痛与阿片类药物成瘾:阿片类药物维持治疗对急性疼痛的长期影响。
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Patterns of physician prescribing for opioid maintenance treatment in Ontario, Canada in 2014.2014年加拿大安大略省阿片类药物维持治疗的医生处方模式。
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Opioid agonist treatment for pharmaceutical opioid dependent people.用于药物性阿片类物质依赖者的阿片类激动剂治疗
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Six-Year Outcome of Opioid Maintenance Treatment in Heroin-Dependent Patients: Results from a Naturalistic Study in a Nationally Representative Sample.海洛因依赖患者阿片类药物维持治疗的六年结果:一项全国代表性样本的自然主义研究结果
Eur Addict Res. 2017;23(2):97-105. doi: 10.1159/000468518. Epub 2017 Apr 5.

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2
Cannabidiol Protects against the Reinstatement of Oxycodone-Induced Conditioned Place Preference in Adolescent Male but Not Female Rats: The Role of MOR and CB1R.大麻二酚可预防阿片类药物诱发的青少年雄性大鼠条件性位置偏爱复吸,但对雌性大鼠无此作用:这与 MOR 和 CB1R 有关。
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County-level factors associated with a mismatch between opioid overdose mortality and availability of opioid treatment facilities.与阿片类药物过量死亡率和阿片类药物治疗设施可及性不匹配相关的县级因素。
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An analog of [d-Trp]CJ-15,208 exhibits kappa opioid receptor antagonism following oral administration and prevents stress-induced reinstatement of extinguished morphine conditioned place preference.[d-Trp]CJ-15,208 的类似物经口服给药后表现出 κ 阿片受体拮抗作用,并可预防应激引起的已消除的吗啡条件性位置偏爱复燃。
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