Sandborn William D, Bendfeldt Fernando, Hamdy Ronald
James H. Quillen School of Medicine of East Tennessee State University.
Am J Geriatr Psychiatry. 1995;3(3):239-242. doi: 10.1097/00019442-199522330-00007. Epub 2012 Aug 15.
The authors present four cases of physically aggressive behavior in geriatric patients with dementia managed with the use of valproic acid. There was improvement in the behavior in most patients; however it was frequently necessary to add a second medication for adequate behavior control, and the side effects were significant.
作者报告了4例使用丙戊酸治疗的老年痴呆患者出现身体攻击行为的病例。大多数患者的行为有所改善;然而,为了充分控制行为,常常需要加用第二种药物,且副作用明显。