从悬铃木花粉中新分离的孢粉素微笼作为可控药物递送载体
Newly isolated sporopollenin microcages from Platanus orientalis pollens as a vehicle for controlled drug delivery.
作者信息
Mujtaba Muhammad, Sargin Idris, Akyuz Lalehan, Ceter Talip, Kaya Murat
机构信息
Aksaray University, Faculty of Science and Letters, Department of Biotechnology and Molecular Biology, 68100 Aksaray, Turkey.
Aksaray University, Technical Vocational School, Department of Chemistry Technology, 68100 Aksaray, Turkey.
出版信息
Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:263-270. doi: 10.1016/j.msec.2017.02.176. Epub 2017 Mar 18.
Sporopollenin microcages were produced from the pollens of Platanus orientalis. Paracetamol was loaded into the microcages. Pollen, sporopollenin, paracetamol and paracetamol-loaded sporopollenin microcages were characterized with FT-IR, TGA and SEM. The analytical analyses demonstrated that sporopollenin microcages were structurally intact, highly reticulated and thermally stable. The loading efficiency of the sporopollenin microcages was found to be 8.2% using the passive loading technique and 23.7% via evaporating loading technique. In vitro release and kinetics studies were performed to test the suitability of sporopollenin microcages for loading. These studies revealed that sporopollenin from P. orientalis can be suggested as a suitable carrier for drug loading and controlled release studies.
悬铃木花粉制备了孢粉素微囊。将对乙酰氨基酚载入微囊中。利用傅里叶变换红外光谱仪（FT-IR）、热重分析仪（TGA）和扫描电子显微镜（SEM）对花粉、孢粉素、对乙酰氨基酚及载药孢粉素微囊进行了表征。分析表明，孢粉素微囊结构完整、高度网状且热稳定性良好。采用被动载入技术时，孢粉素微囊的载入效率为8.2%，通过蒸发载入技术则为23.7%。进行了体外释放和动力学研究以测试孢粉素微囊用于载药的适用性。这些研究表明，东方悬铃木的孢粉素可作为药物载入及控释研究的合适载体。
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