基于孢粉素的微胶囊的种特异性生物降解。
Species-Specific Biodegradation of Sporopollenin-Based Microcapsules.
机构信息
School of Materials Science and Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore, Singapore.
Department of Materials and Chemistry, Nanomaterials Research Institute (NMRI), National Institute of Advanced Industrial Science and Technology (AIST), Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8565, Japan.
出版信息
Sci Rep. 2019 Jul 3;9(1):9626. doi: 10.1038/s41598-019-46131-w.
Sporoderms, the outer layers of plant spores and pollen grains, are some of the most robust biomaterials in nature. In order to evaluate the potential of sporoderms in biomedical applications, we studied the biodegradation in simulated gastrointestinal fluid of sporoderm microcapsules (SDMCs) derived from four different plant species: lycopodium (Lycopodium clavatum L.), camellia (Camellia sinensis L.), cattail (Typha angustifolia L.), and dandelion (Taraxacum officinale L.). Dynamic image particle analysis (DIPA) and field-emission scanning electron microscopy (FE-SEM) were used to investigate the morphological characteristics of the capsules, and Fourier-transform infrared (FTIR) spectroscopy was used to evaluate their chemical properties. We found that SDMCs undergo bulk degradation in a species-dependent manner, with camellia SDMCs undergoing the most extensive degradation, and dandelion and lycopodium SDMCs being the most robust.
孢子外壁，是植物孢子和花粉粒的外层，是自然界中最具韧性的生物材料之一。为了评估孢子外壁在生物医学应用中的潜力，我们研究了来自四种不同植物物种的孢子外壁微胶囊（SDMC）在模拟胃肠道液中的生物降解情况：石松（Lycopodium clavatum L.）、茶（Camellia sinensis L.）、香蒲（Typha angustifolia L.）和蒲公英（Taraxacum officinale L.）。动态图像粒子分析（DIPA）和场发射扫描电子显微镜（FE-SEM）用于研究胶囊的形态特征，傅里叶变换红外（FTIR）光谱用于评估其化学性质。我们发现 SDMC 以依赖于物种的方式进行整体降解，其中茶 SDMC 经历了最广泛的降解，而蒲公英和石松 SDMC 则最为坚固。
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