Antitumor activity and safety evaluation of nanaparticle-based delivery of quercetin through intravenous administration in mice.

The present study focused on the inhibition effects and the safety evaluation of the quercetin when it was loaded into the nanoliposomes on cervical cancer in vitro and in vivo. Quercetin loaded nanoliposomes (Que-NLs) were first prepared by thin film hydration method and the characterizations of Que-NLs were measured with TEM and dynamic light scattering (DLS) techniques. Then the anti-cervical cancer efficiencies were evaluated by MTT and U14 tumor-bearing mice models in vitro and in vivo respectively. The body changes, organ index, biochemical criterions and histopathological of livers and kidneys in tumor-bearing mice were further assayed to evaluate the safety of Que-NLs. In vitro results showed that Que-NLs have a low IC value compared with free-Que, thus leading to the stronger antitumor efficacy to Hela cells. In vivo results further demonstrated that the Que-NLs display a higher inhibition effect on U14 cervical cancer compared with free-Que caused no obvious hepatic toxicity or kidney dysfunction in Balb/c mice. So we concluded that Que-NLs possess effective anti-cervical cancer properties and does not exhibit the notable adverse effects associated with cervical cancer.