Umesh Mahantshetty, Kumar Deepak P, Chadha Pranav, Choudary Rajiv, Kembhavi Seema, Thakur Meenakshi, Reena Engineer, Chopra Supriya, Shrivastava Shyamkishore
Department of Radiation Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India.
Department of Radiodiagnosis, Tata Memorial Centre, Mumbai, Maharashtra, India.
Technol Cancer Res Treat. 2017 Dec;16(6):917-922. doi: 10.1177/1533034617709596. Epub 2017 May 22.
Advanced radiotherapy techniques have emphasized on the importance of accurate target volume localization and delineation. The aim of this study was to determine time taken to achieve moderate bladder volume under physiological conditions, using transabdominal ultrasound.
Patients with cervical cancer undergoing radical radiation with or without concomitant chemotherapy underwent serial ultrasound to estimate bladder filling. With a strict bladder protocol of consuming 1000 mL of water orally over 30 minutes after emptying the bladder, ultrasound was done after 45 minutes from bladder emptying time and repeated at 15-minute interval till 300 (25) mL filling was achieved and repeated every week.
Forty-six patients with weekly ultrasound for bladder-filling documentation were evaluated. The mean (standard deviation) bladder volume measured at 45 minutes was 220 (93), 210 (95), 195 (91), 195 (96), and 190 (85) mL (average: 200; median: 195 mL) for the first to fifth week, respectively, and the mean (standard deviation) volume at 75 minutes was 300 (95), 310 (80), 290 (80), 295 (80), and 285 (70) mL (average: 295; median: 300 mL). The mean (standard deviation) time for bladder filling to 300 mL in the first, second, third, fourth, and fifth week was 57 ( 13.5), 67 (16.6), 66 (16.7), 66 (15.5), and 69 (17.1) minutes, respectively.
Bladder filling to a definitive moderate volume at a reasonably fixed time period in each week of radiation is well tolerated, feasible, and measurable by weekly transabdominal ultrasound measurements.
先进的放射治疗技术强调了精确靶区定位和勾画的重要性。本研究的目的是使用经腹超声确定在生理条件下达到适度膀胱容量所需的时间。
接受根治性放疗（伴或不伴同步化疗）的宫颈癌患者接受系列超声检查以评估膀胱充盈情况。采用严格的膀胱方案，在排空膀胱后30分钟内口服1000 mL水，从膀胱排空时间起45分钟后进行超声检查，并每隔15分钟重复检查一次，直至膀胱充盈至300（25）mL，之后每周重复检查。
对46例每周进行超声检查以记录膀胱充盈情况的患者进行了评估。在第一至第五周，45分钟时测量的平均（标准差）膀胱容量分别为220（93）、210（95）、195（91）、195（96）和190（85）mL（平均：(200)；中位数：(195) mL），75分钟时的平均（标准差）容量分别为300（95）、310（80）、290（80）、295（80）和285（70）mL（平均：(295)；中位数：(300) mL）。第一、第二、第三、第四和第五周膀胱充盈至300 mL的平均（标准差）时间分别为57（13.5）、67（16.6）、66（16.7）、66（15.5）和69（17.1）分钟。
在放疗的每周合理固定时间段内，膀胱充盈至确定的适度容量耐受性良好、可行，并且可通过每周经腹超声测量进行监测。
