哇巴因、胰岛素和环磷酸腺苷对牛蛙肾近端小管管腔液酸化的影响。

The effect of ouabain, insulin, and cyclic AMP on the acidification of luminal fluid in the proximal tubule of bullfrog kidney.

作者信息

Kubota T, Hagiwara N, Inoue A, Fujimoto M

机构信息

Department of Physiology, Osaka Medical College, Japan.

出版信息

Jpn J Physiol. 1988;38(4):549-56. doi: 10.2170/jjphysiol.38.549.

DOI:10.2170/jjphysiol.38.549

PMID:2853241

Abstract

A transient urinary acidification was induced in the bullfrog proximal tubule by the peritubular administration of ouabain (10(-4) M). Insulin (200 mIU/ml) provoked a prolonged decrease of tubular fluid pH (TFpH), whereas dibutyryl cyclic AMP (10(-4) M) produced a transient increase of TFpH. The above data support the view that the urinary acidification in the proximal tubule is not explained by a simple mechanism, such as Na+/H+ exchange.

摘要

通过在牛蛙近端小管的肾小管周围给予哇巴因（10⁻⁴ M）诱导了短暂的尿液酸化。胰岛素（200 mIU/ml）引起肾小管液pH值（TFpH）的持续下降，而二丁酰环磷酸腺苷（10⁻⁴ M）则使TFpH短暂升高。上述数据支持近端小管中的尿液酸化不能用诸如Na⁺/H⁺交换等简单机制来解释这一观点。