Department of Cardiac Surgery, The Royal Children's Hospital, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Australia; Heart Research, Clinical Sciences, Murdoch Childrens Research Institute, Melbourne, Australia.
Fetal Heart Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Int J Cardiol. 2017 Oct 15;245:131-134. doi: 10.1016/j.ijcard.2017.05.027. Epub 2017 May 11.
A growing population of patients are now surviving the Fontan procedure and face an uncertain future and a clear burden of disease. The best medical therapy and follow-up modalities for these patients have not yet been identified, indications for transplantation are unclear and we have not been successful in mechanically supporting their circulation. There has only been a limited number of trials to address these issues. An international group has now been created to launch the large scale multi-centric research needed to provide the best future to this growing population: the International Fontan Interest Group (I-FIG). Its mission is to "better understand the Fontan circulation, and improve treatment and long-term outcomes of the patients who have undergone the Fontan procedure". We intend to build a large platform which will attract researchers of other specialties such as gastro-enterology, neurology and psychology and reach in the field of genomics, molecular biology, pharmacology and bio-informatics.
越来越多的患者成功地接受了 Fontan 手术，但他们未来的健康状况仍不确定，疾病负担也很沉重。目前尚未确定此类患者的最佳医疗治疗和随访方式，移植的适应证也不明确，我们在机械循环支持方面也尚未取得成功。针对这些问题，我们仅开展了有限数量的试验。目前已成立了一个国际组织，旨在开展大规模的多中心研究，为这一不断增长的患者群体提供最佳的未来：国际 Fontan 兴趣小组（I-FIG）。其使命是“更好地了解 Fontan 循环，并改善接受过 Fontan 手术的患者的治疗和长期预后”。我们打算搭建一个大型平台，吸引胃肠病学、神经病学和心理学等其他专业的研究人员，并在基因组学、分子生物学、药理学和生物信息学领域取得进展。
