Piccione N
Minerva Stomatol. 1978 Jul-Sep;27(3):195-201.
The therapeutic effect and clinical tolerance of an association of spiramycin and metronidazole were assessed in 20 patients with odontostomatological inflammation. The results were regarded as satisfactory with regard to the length of treatment and the progression of the clinical picture in 90% of the cases treated. Unwanted side-effects, not sufficiently severe to stop the treatment, were noted in only 2 cases. Comparison with the results obtained in a control series treated with spiramycin only showed that the combination was more effective, though the difference was not significant, and letter tolerated.
对20例口腔颌面部炎症患者评估了螺旋霉素与甲硝唑联合用药的治疗效果及临床耐受性。在90%的治疗病例中,就治疗时长和临床表现进展而言,结果被认为是令人满意的。仅2例出现了虽严重程度不足以导致停药但仍属不良的副作用。与仅用螺旋霉素治疗的对照系列所获结果相比,表明联合用药更有效,尽管差异不显著,且耐受性更佳。