Hadley M E
Department of Anatomy, Arizona Health Sciences, College of Medicine, Tucson 85724.
Pigment Cell Res. 1987;1(1):57-61. doi: 10.1111/j.1600-0749.1987.tb00535.x.
The calcium ionophore, A231187, induces a Ca2+ -dependent movement (dispersion) of melanosomes within skin melanophores of the lizard, Anolis carolinensis, in vitro. The effects of A23187 are irreversible, since after repeated rinsing of the skins in the absence of the ionophore they will always darken in Ringer containing Ca2+ but will immediately lighten when transferred to Ca2+ -free Ringer. These results suggest that the ionophore is irreversibly localized to the melanophore membrane and that its melanosome-dispersing effect is continuously dependent upon extracellular calcium.
钙离子载体A231187在体外可诱导变色蜥（安乐蜥）皮肤黑素细胞内的黑素小体发生钙离子依赖性移动（分散）。A23187的作用是不可逆的，因为在不含离子载体的情况下反复冲洗皮肤后，皮肤在含有钙离子的林格氏液中总会变黑，但转移至无钙林格氏液中时会立即变浅。这些结果表明，离子载体不可逆地定位于黑素细胞膜，其黑素小体分散效应持续依赖于细胞外钙。
