[氢化可的松对大鼠脑嗅皮质存活切片中突触传递的影响]

[Effect of hydrocortisone on synaptic transmission in surviving slices of the olfactory cortex from the rat brain].

作者信息

Mokrushin A A, Bagaeva T R, Gerasimova I A, Emel'ianov N A

出版信息

Probl Endokrinol (Mosk). 1988 Nov-Dec;34(6):52-6.

Abstract

A study was made of the effect of bath-applied hydrocortisone (10(-4) M) on excitatory transmission of the lateral olfactory tract (LOT) - superficial pyramidal cell synapse of the rat olfactory cortex slice. Population EPSP and IPSP were depressed for 6-12 min., then they were increased (60 min.) by hydrocortisone. Recovery of evoked potentials was long (40-60 min.) at washing of slices hy a normal incubation medium. Habituation of synaptic potentials during LOT repeating stimulation was deteriorated by hydrocortisone application in perfusion solution. The data obtained were considered to be adaptive functions of the nervous system to a stressor.

摘要

研究了浴用氢化可的松（10⁻⁴ M）对大鼠嗅皮质切片外侧嗅束（LOT）-浅层锥体细胞突触兴奋性传递的影响。群体兴奋性突触后电位（EPSP）和抑制性突触后电位（IPSP）在6 - 12分钟内受到抑制，然后氢化可的松使其升高（60分钟）。用正常孵育培养基冲洗切片时，诱发电位的恢复时间较长（40 - 60分钟）。在灌注溶液中应用氢化可的松会使LOT重复刺激期间突触电位的习惯化恶化。所获得的数据被认为是神经系统对应激源的适应性功能。