男性乳腺癌内在分子亚型的预后意义。

Prognostic implications of the intrinsic molecular subtypes in male breast cancer.

作者信息

Abdeljaoued Syrine, Lhem Bettaieb, Nasri Meher, Adouni Olfa, Goucha Goucha Aida, Bouzaiene Hatem, Boussen Hamouda, Rahal Rahal Khaled, Gamoudi Gamoudi Amor

机构信息

Department of Immuno-Histo-Cytology, Salah Azaïz Cancer Institute, Bab Saadoun, 1006, Tunis, Tunisia.

出版信息

J BUON. 2017 Mar-Apr;22(2):377-382.

PMID:28534358

Abstract

PURPOSE

Intrinsic molecular subtyping has been widely used in female breast cancer, and it has proven its significance. In this article, we aimed to study the intrinsic subtypes of male breast cancer (MBC) in correlation with clinicopathological features.

METHODS

We retrospectively identified 130 MBC cases from 2004 to 2013. Intrinsic molecular subtypes were determined by immunohistochemistry (IHC).

RESULTS

From a total of 130 MBC cases, 45.4% of tumors were luminal A subtype, 44.6% were luminal B, 5% were HER2 positive and 5% were triple negative tumors. There were statistically significant differences between different IHC intrinsic subtypes regarding tumor size (p=0.001), estrogen receptor (ER) status (p=0.001), progesterone receptor (PR) status (p=0.001), HER2 status (p=0.001) and Ki67 proliferation index (p=0.001).

CONCLUSION

The distribution of breast cancer intrinsic subtypes in males is different compared to its female counterpart; however, they don't seem to give the same prognostic value.

摘要

目的

内在分子分型已在女性乳腺癌中广泛应用，并已证明其重要性。在本文中，我们旨在研究男性乳腺癌（MBC）的内在亚型及其与临床病理特征的相关性。

方法

我们回顾性地确定了2004年至2013年期间的130例MBC病例。通过免疫组织化学（IHC）确定内在分子亚型。

结果

在总共130例MBC病例中，45.4%的肿瘤为腔面A型，44.6%为腔面B型，5%为HER2阳性，5%为三阴性肿瘤。不同IHC内在亚型在肿瘤大小（p=0.001）、雌激素受体（ER）状态（p=0.001）、孕激素受体（PR）状态（p=0.001）、HER2状态（p=0.001）和Ki67增殖指数（p=0.001）方面存在统计学显著差异。