Frøssing Signe, Nylander Malin Chatarina, Chabanova Elizaveta, Kistorp Caroline, Skouby Sven O, Faber Jens
1 Center of Endocrinology and Metabolism, Dept. of Internal medicine, Herlev Gentofte Hospital, Denmark.
2 Dept. of Obstetrics and Gynecology, Herlev Gentofte Hospital, Denmark.
Acta Radiol. 2018 Jan;59(1):13-17. doi: 10.1177/0284185117711475. Epub 2017 May 23.
Background Polycystic ovary syndrome (PCOS) is associated with frequent overweight and abdominal obesity. Quantifying visceral adipose tissue (VAT) in PCOS patients can be a tool to assess metabolic risk and monitor effects of treatment. The latest dual-energy X-ray absorptiometry (DXA) technology can measure VAT and subcutaneous adipose tissue (SAT) in a clinical setting. Purpose To compare DXA-measurements of VAT and SAT with the gold standard MRI in women with PCOS. Material and Methods A cross-sectional study of 67 overweight women with PCOS was performed. Measurements of VAT and SAT were performed by DXA in a 5-cm thick transverse slice at the L4/L5 level and by MRI in a 1-cm thick transverse slice at the L3 level. Results Mean (SD) DXA-VAT was 81 (34) cm, DXA-SAT was 498 (118) cm, MRI-VAT was 117 (48) cm, and MRI-SAT was 408 (122) cm. MRI and DXA measures of VAT (r = 0.82, P < 0.001) and SAT (r = 0.92, P < 0.001) correlated closely, and DXA-VAT was stronger correlated with MRI-VAT than BMI (r = 0.62, P < 0.001) and waist circumference (r = 0.60, P < 0.001). DXA-VAT coefficient of variance was 6.7% and inter correlation coefficient was 0.98. Bland-Altman analyses showed DXA to slightly underestimate VAT and SAT measurements compared with MRI. Conclusion DXA and MRI measurements of VAT and SAT correlated closely despite different size of region of interest, and DXA-VAT was superior to waist circumference and BMI in estimating MRI-VAT. DXA showed high reproducibility making it is suitable for repeated measurements in the same individual over time.
多囊卵巢综合征（PCOS）常伴有超重和腹部肥胖。对PCOS患者的内脏脂肪组织（VAT）进行量化可作为评估代谢风险和监测治疗效果的一种手段。最新的双能X线吸收法（DXA）技术能够在临床环境中测量VAT和皮下脂肪组织（SAT）。目的：比较PCOS女性中DXA测量的VAT和SAT与金标准MRI测量结果。材料与方法：对67名超重PCOS女性进行了一项横断面研究。通过DXA在L4/L5水平的5厘米厚横向切片上测量VAT和SAT，通过MRI在L3水平的1厘米厚横向切片上测量。结果：DXA测量的平均（标准差）VAT为81（34）立方厘米，DXA测量的SAT为498（118）立方厘米，MRI测量的VAT为117（48）立方厘米，MRI测量的SAT为408（122）立方厘米。MRI和DXA测量的VAT（r = 0.82，P < 0.001）和SAT（r = 0.92，P < 0.001）密切相关，且DXA测量的VAT与MRI测量的VAT的相关性比体重指数（BMI，r = 0.62，P < 0.001）和腰围（r = 0.60，P < 0.001）更强。DXA测量的VAT变异系数为6.7%，内部相关系数为0.98。Bland-Altman分析表明，与MRI相比，DXA会略微低估VAT和SAT的测量值。结论：尽管感兴趣区域大小不同，但DXA和MRI对VAT和SAT的测量密切相关，且在估计MRI测量的VAT方面，DXA测量的VAT优于腰围和BMI。DXA显示出高重现性，使其适用于对同一个体随时间进行重复测量。
