镧系铂配合物：通过铂-脱氧核糖核酸交联靶向染色核仁的铕（III）和铽（III）发光配合物
Lanthanoplatins: emissive Eu(iii) and Tb(iii) complexes staining nucleoli targeted through Pt-DNA crosslinking.
作者信息
Singh Khushbu, Singh Swati, Srivastava Payal, Sivakumar Sri, Patra Ashis K
机构信息
Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, Uttar Pradesh, India.
出版信息
Chem Commun (Camb). 2017 Jun 1;53(45):6144-6147. doi: 10.1039/c7cc02047c.
Two highly luminescent water-soluble heterometallic LnPt complexes, {cis-PtCl(NH)}Ln(L)(HO) (Ln = Eu (1), Tb (2)), have been designed for their selective nucleoli staining through formation of Pt-DNA crosslinks. The complexes showed significant cellular uptake and distinctive nucleoli localization through intrinsic emission from Eu or Tb observed through confocal fluorescence microscopy.
两种高发光的水溶性异金属镧系铂配合物，{顺式 - 铂氯（氨）}镧系元素（L）（水）（镧系元素 = 铕（1），铽（2）），已被设计用于通过形成铂 - DNA交联进行选择性核仁染色。通过共聚焦荧光显微镜观察到，这些配合物通过铕或铽的本征发射显示出显著的细胞摄取和独特的核仁定位。
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