School of Chemistry, National University of Ireland, Galway, University Road, Galway, Ireland.
Dalton Trans. 2017 Jun 6;46(22):7242-7252. doi: 10.1039/c7dt01091e.
The successful design, synthesis, characterization, photophysical properties and anticancer mechanistic studies of a series of half-sandwich cyclopentadienyl iridium(iii) complexes of the type Cp*Ir(LC)(L1), 1, and Cp*Ir(LC)(L2), 2, in which Cp* = pentamethylcyclopentadienyl, L1 = 4-(pyren-10-yl)ethynyl-phenylcyanamide, L2 = 4'-(pyren-10-yl)ethynyl-4-cyanamidobiphenyl, and LC = lidocaine, are reported for their application as photodynamic therapy (PDT) agents. The DNA binding, DNA photocleavage, cellular uptake, and apoptosis of the complexes have also been studied.
报道了一系列半夹心环戊二烯基铱(III)配合物Cp*Ir(LC)(L1)，1 和 Cp*Ir(LC)(L2)，2 的成功设计、合成、表征、光物理性质和抗癌机制研究，其中 Cp* = 五甲基环戊二烯基，L1 = 4-(芘-10-基)乙炔基-苯甲腈酰胺，L2 = 4'-(芘-10-基)乙炔基-4-氰基联苯，LC = 利多卡因，它们被用作光动力疗法 (PDT) 试剂。还研究了配合物的 DNA 结合、DNA 光解、细胞摄取和细胞凋亡。
