Oberhoffer R, Kupferschmid C, Lang D
Abteilung Pädiatrie I, Universitäts-Kinderklinik, Ulm, Bundesrepublik Deutschland.
Wien Klin Wochenschr. 1988 Dec 16;100(24):797-801.
Secondary hypertrophic cardiomyopathy (HCM) was diagnosed in 55 newborns and infants without heart disease. The 17 newborn infants of diabetic mothers, 23 infants given ACTH treatment for infantile spasms, 9 ventilated premature infants or babies with bronchopulmonary dysplasia and 6 infants with different underlying diseases comprising this group underwent 2-dimensional echocardiography. In almost all cases echocardiographic evidence of HCM resolved after removal of the exogenous or endogenous causative factor. Myocardial effects of several substances are known and their pathophysiological mechanisms are discussed. Since HCM may precede systemic disease or may often be the first pointer to a triggering agent, further diagnostic procedures are always indicated. Hence, the diagnosis of primary HCM should be made by exclusion.
55例无心脏病的新生儿和婴儿被诊断为继发性肥厚型心肌病（HCM）。该组包括17例患有糖尿病母亲的新生儿、23例因婴儿痉挛接受促肾上腺皮质激素（ACTH）治疗的婴儿、9例接受通气治疗的早产儿或患有支气管肺发育不良的婴儿以及6例患有不同基础疾病的婴儿，均接受了二维超声心动图检查。在几乎所有病例中，去除外源性或内源性致病因素后，HCM的超声心动图证据均消失。几种物质对心肌的影响是已知的，并对其病理生理机制进行了讨论。由于HCM可能先于全身性疾病出现，或者常常是触发因素的首个指示，因此总是需要进一步的诊断程序。因此，原发性HCM应通过排除法进行诊断。
