Pax2：在瓦丁顿的表观遗传景观上的“保持在道路上”的标志。
Pax2: A "Keep to the Path" Sign on Waddington's Epigenetic Landscape.
机构信息
College of Medicine, University of Edinburgh, Edinburgh EH8 9XB, UK.
出版信息
Dev Cell. 2017 May 22;41(4):331-332. doi: 10.1016/j.devcel.2017.05.006.
PMID:28535367
Abstract
Developing kidneys have Foxd1 stromogenic stem cells and [Six2, Pax2] nephrogenic stem cells. In this issue of Developmental Cell, Naiman et al. (2017) show that targeted Pax2 deletion converts nephrogenic cells to the stromogenic path, suggesting that Pax2 normally represses an otherwise inevitable transition between sister lineages.
摘要
发育中的肾脏具有 Foxd1 基质生成干细胞和 [Six2, Pax2] 肾发生干细胞。在本期《发育细胞》中，Naiman 等人（2017）表明，靶向 Pax2 缺失将肾发生细胞转化为基质生成途径，表明 Pax2 通常抑制姐妹谱系之间不可避免的转变。
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