Bellan M, Pirisi M, Bellomo G, Sainaghi P P
Department of Translational Medicine, Università del Piemonte Orientale UPO, Novara; Division of Internal Medicine, Immunorheumatology Unit, AOU Maggiore della Carità, Novara.
Reumatismo. 2017 May 22;69(1):40-42. doi: 10.4081/reumatismo.2017.941.
Troponin I (TnI) false positive results have been reported in patients affected by immune disorders. We report the case of a 74-year-old woman affected by cryoglobulinemic vasculitis, admitted to the Emergency Room because of a lipotimic episode. A marked elevation of TnI plasma concentration was confirmed in multiple determinations, despite the absence of symptoms or electrocardiogram findings suggesting myocardial infarction. TnI plasma concentration was reported normal after re-testing with a different commercial kit. A false TnI positivity should be considered in patients with immune disorders, especially if seropositive for rheumatoid factor, when the clinical context does not suggest myocardial infarction.
已有报道称，免疫紊乱患者会出现肌钙蛋白I（TnI）假阳性结果。我们报告了一例74岁患有冷球蛋白血症性血管炎的女性病例，该患者因晕厥发作被送往急诊室。尽管没有提示心肌梗死的症状或心电图表现，但多次检测均证实其血浆TnI浓度显著升高。使用不同的商业试剂盒重新检测后，血浆TnI浓度报告为正常。对于免疫紊乱患者，尤其是类风湿因子血清学阳性且临床情况不提示心肌梗死时，应考虑TnI假阳性。
