Nannini Margherita, Urbini Milena, Astolfi Annalisa, Biasco Guido, Pantaleo Maria A
Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
"Giorgio Prodi" Cancer Research Center, University of Bologna, Bologna, Italy.
J Transl Med. 2017 May 23;15(1):113. doi: 10.1186/s12967-017-1212-x.
Recent advances in molecular biology have revolutionized the concept of KIT/PDGFRA wild type (WT) gastrointestinal stromal tumors (GIST) than the past. Indeed, from being defined as GIST without KIT or PDGFRA mutations, we are now faced with the opposite scenario, where KIT/PDGFRA WT GIST are "positively" defined according to their specific molecular alterations. In particular, if until recently KIT/PDGFRA GIST without abnormalities of KIT, PDGFRA, SDH, and the RAS signaling pathway were referred as quadruple WT GIST, today also this small subset of GIST is emerging out as a group of heterogeneous distinct entities with multiple different molecular alterations. Therefore, given this still growing and rapidly evolving scenario, the progressive molecular fragmentation may inevitably lead over the time to the disappearance of KIT/PDGFRA WT GIST, destined to be singularly defined by their molecular fingerprint.
与过去相比，分子生物学的最新进展彻底改变了KIT/PDGFRA野生型（WT）胃肠道间质瘤（GIST）的概念。实际上，过去将其定义为无KIT或PDGFRA突变的GIST，而现在我们面临着相反的情况，即KIT/PDGFRA WT GIST是根据其特定的分子改变进行“正向”定义的。特别是，直到最近，无KIT、PDGFRA、SDH和RAS信号通路异常的KIT/PDGFRA GIST被称为四重野生型GIST，而如今，这一小部分GIST也正作为一组具有多种不同分子改变的异质性不同实体而出现。因此，鉴于这种仍在不断发展且迅速演变的情况，随着时间的推移，这种逐渐的分子碎片化可能不可避免地导致KIT/PDGFRA WT GIST的消失，它们注定要通过其分子指纹进行单独定义。
